Directory of funded grants

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556 results found

Regulation of endosomal membrane trafficking by C9ORF72 in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2016

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Dr. Peter McPherson, professor at the Montreal Neurological Institute, McGill University will receive one year of support to work on the connection between the most prominent known cause of ALS, a mutation in a gene called C9ORF72, and a previously unrelated critical cellular function called endosomal membrane trafficking. Endosomal membrane…

Identification of circulating non-coding RNAs with diagnostic relevance in ALS patients using a unique extracellular vesicle capture method

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    New Brunswick

  • Start Date

    2015

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Earlier diagnosis of ALS remains one of the biggest goals of researchers worldwide and it is likely that the effectiveness of future treatment discoveries will be magnified by their application at a time point closer to symptom onset. To date, achieving a definitive diagnosis of ALS often remains a slow…

A Novel Microfluidic Platform for Investigating Axonal Sprouting in Motor Neurons

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Alberta

  • Start Date

    2016

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Motor neurons are extremely complex cells. Not only do they have an intricate set of inner workings, but they have a long wire-like portion called an axon that connects the central nervous system to muscles called an axon. Understanding all of the aspects of how axons are guided through the…

A Randomized Controlled Trial of Pimozide in Subjects with ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Alberta

  • Start Date

    2016

  • Total Grant Amount

    $489,856

  • Health Canada Contribution

    $244,928

Project Overview

This project is a Phase II study involving 100 participants across 8 ALS clinics across Canada. The trial, led by the Principal Investigator of the Canadian Neuromuscular Disease Registry (CNDR) and the Chair of the Canadian ALS Research Network (CALS) will examine whether pimozide, a drug already approved by Health…

Synaptic inhibition in the motor cortex of an ALS mouse model

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

ALS is a disease characterized by degeneration of both upper and lower motor neurons. Upper motor neurons are located in a region of the brain called the motor cortex and have been far less extensively studied than lower motor neurons in the spinal cord. One of the earliest detectable abnormalities…