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Novel blood and neuroimaging markers of Alzheimer’s disease and cerebral amyloid angiopathy

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    2015 MIRI Team Grants

  • Province

    Alberta

  • Start Date

    2016

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

As our brains age, they become vulnerable to diseases such as Alzheimer’s disease which can cause dementia. Dementia is defined as cognitive (i.e., thinking) problems that interfere with usual daily activities. In the milder stages of dementia, this includes difficulty with shopping, finances, and cooking. As dementia progresses, difficulties with…

Combining neurostimulation technique with tailored interventions for the affected upper extremity: can it promote better recovery in stroke survivors?

  • Program Type

    Team grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    2015 MIRI Team Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $321,303

  • Health Canada Contribution

    $160,651

Project Overview

A substantial proportion of individuals are left with poor residual functioning of the affected arm after a stroke. This has a tremendous impact on the quality of life and the ability for stroke survivors to live independently. While exercise is considered essential to any rehabilitation program, its benefits are generally…

Montreal integrated neuropsychiatric cohort: Identifying subtypes of Autism and Schizophrenia integrating genomics, endophenotypes, and cohorts of high-risk genetic variants

  • Program Type

    Team grants

  • Area of research

    Multiple

  • Disease Area

    AutismMental illness

  • Competition

    2015 MIRI Team Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ. This suggests that many different mechanisms are causing these disorders in patients. This great diversity has hindered…

Preclinical development of a disease modifying small molecule therapy for Alzheimer disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    BC Alzheimer's Research Award Program

  • Province

    British Columbia

  • Start Date

    2015

  • Total Grant Amount

    $1,410,000

  • Health Canada Contribution

    $705,000

Project Overview

No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Several dramatic late stage clinical failures have heightened recognition that novel approaches need to be quickly pursued in order to develop useful treatments for the aging population. The two pathological hallmarks of AD are protein…

Validation of Connexins and Pannexins as a target for Alzheimer’s Disease

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    BC Alzheimer's Research Award Program

  • Province

    British Columbia

  • Start Date

    2014

  • Total Grant Amount

    $1,410,000

  • Health Canada Contribution

    $705,000

Project Overview

Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. This number is estimated to increase to over 75 million in 2030; 1.4 million of these will be in Canada. Today,…