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Brain imaging using magnetic resonance imaging (MRI) is an essential tool in modern neuroscience, with many uses for examining brain structure and function in health and disease. Project Overview Brain imaging using magnetic resonance imaging (MRI) is an essential tool in modern neuroscience, with...

The choroid plexus (CP) is a secretory tissue found in each of the brain ventricles. Project Overview The choroid plexus (CP) is a secretory tissue found in each of the brain ventricles. The CP produces a clear fluid called cerebrospinal fluid (CSF) which helps to cushion the brain, to circulate...

This research is motivated by the Canadian Dementia Strategy priority and urgent need to “build the evidence base to inform and promote the adoption of effective interventions” for dementia prevention. Project Overview This research is motivated by the Canadian Dementia Strategy priority and urgent...

Fragile X syndrome (FXS) is the first inherited cause of intellectual disability and one of the most prevalent causes of autism spectrum disorders. Project Overview Fragile X syndrome (FXS) is the first inherited cause of intellectual disability and one of the most prevalent causes of autism...

Medulloblastoma is a pediatric cancer of the brain and is the most common solid tumour in children. Project Overview Medulloblastoma is a pediatric cancer of the brain and is the most common solid tumour in children. Currently, the standard therapy for medulloblastoma remains nonspecific to the...

Amyotrophic Lateral Sclerosis (ALS) is a progressive disease that destroys the motor neurons needed for movement, speech, and breathing, but new research shows that other spinal cord cells called interneurons may be affected even earlier. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a...

For this project, Dr. Park will examine how abnormalities in RNA binding proteins (RBPs) – in particular, one called Matrin 3 (MATR3) – can lead to ALS. MATR3 was discovered to be a genetic cause of ALS in 2014 and has yet to be studied in any detail. Project Overview For this project, Dr. Park...

The key neuropathology underlying ASDs is abnormal neuronal communication as a result of altered synapse formation, function and plasticity. Project Overview The key neuropathology underlying ASDs is abnormal neuronal communication as a result of altered synapse formation, function and plasticity....

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes. Project Overview A group of viruses called enteroviruses can cause a variety of infectious...

A significant proportion of critically ill children experience delirium, a form of brain dysfunction associated with adverse outcomes. Project Overview A significant proportion of critically ill children experience delirium, a form of brain dysfunction associated with adverse outcomes. In children,...