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Retina-based optogenetic therapy is a promising approach to restore vision to individuals suffering from retinal degeneration. Project Overview Retina-based optogenetic therapy is a promising approach to restore vision to individuals suffering from retinal degeneration. After photoreceptor...

The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral blood flow (CBF) regulation in different regions of their brain. Project Overview The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral...

In late 2011, a landmark discovery was made which identified that abnormalities (mutation) in a gene called C9ORF72 were responsible for the highest percentage of hereditary ALS and frontotemporal dementia cases. Project Overview In late 2011, a landmark discovery was made which identified that...

A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. Project Overview A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. We have identified a process called “SUMOylation” that...

The human brain is made up of neural circuits that are thought to underlie all brain function. Project Overview The human brain is made up of neural circuits that are thought to underlie all brain function. These circuits are made up of contact points called synapses where individual nerve cells...

The development of approaches to aid early detection of the transition from healthy aging to mild cognitive impairment and Alzheimer’s disease (AD) is critically important for developing targeted strategies to halt or slow disease progression. Project Overview The development of approaches to aid...

Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body temperature control the best known examples. Project Overview Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body...

Many people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to stop walking unexpectedly and makes them more likely to fall. Project Overview Many people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to...

Autism is a neuro-developmental disorder characterized by social/communication deficits and repetitive behaviours. Project Overview Autism is a neuro-developmental disorder characterized by social/communication deficits and repetitive behaviours. It is very heterogeneous, with over 250 genes...

Each year, over 312 million patients undergo surgery. Project Overview Each year, over 312 million patients undergo surgery. Anesthesia is a drug-induced reversible, comatose state that facilitates surgery. It is widely assumed cognition returns to baseline afterwards. Surgery and anesthesia...