Alzheimer’s disease can affect memory and thinking by changing how brain cells communicate. Our project looks at early changes in the hippocampus, a part of the brain important for learning and memory. We are focusing on a small group of brain cells – VIP interneurons – that help control the flow of information during memory formation. Our previous work suggests that these cells may stop working properly before major memory problems appear. In this study, we will test whether restoring their activity can improve memory in a mouse model of Alzheimer’s disease. Rather than focusing only on the buildup of disease-related proteins, this project explores whether repairing brain communication networks could help protect memory earlier. The long-term goal is to support the development of new approaches that may help people living with dementia maintain brain function, independence, and quality of life for longer.
