Cellular immunotherapy is an exciting new way of treating disease by using the body’s own immune system to find and destroy cancer cells. This approach has great promise for treating glioblastoma, one of the most aggressive and hardest-to-treat brain cancers. One of the biggest challenges is that tumours can protect themselves by weakening the immune system and preventing immune cells from reaching and attacking the cancer. We propose a new, image-guided treatment that uses safe, non-invasive ultrasound waves together with tiny, vibrating bubbles to help immune cells enter the tumour more easily and work more effectively. By focusing these sound waves directly on the tumour, we can guide immune cells to the cancer site and activate helpful genes inside them. This boosts the immune cells’ strength, survival, and ability to continue fighting the cancer over time.
