Subventions financées

"Background:Within the realm of neurodegenerative diseases, there is still a lack of effective disease-modifying treatments. Huntington’s Disease (HD) is no less immune to this issue, with only symptomatic treatment options being available for patients."

The increasing prevalence of anxio-depressive disorders worldwide suggests that current therapeutic strategies are insufficient in tackling this global health concern.

"Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and cognitive decline."

Women have a higher lifetime risk of Alzheimer’s disease (AD), possibly due to female-specific factors like menopause and pregnancy history.

The Challenge: Current therapies for treating a number of mental health disorders – depression, anxiety,
and PTSD, among them – adequately treat only a small fraction of afflicted patients.

This project explores how people living with dementia and their caregivers create clever do-it-yourself (DIY) solutions to make everyday tasks at home easier and safer.

Apathy (reduced goal-directed behaviour) is common in persons with dementia and is associated with lower quality of life, increased dependence and faster decline.

“Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been documented in Huntington’s disease (HD).

"Antisense oligonucleotides (ASOs) are synthetic single-stranded DNA/RNA that are useful in the targeting of mRNA sequences."

One in five older adults with dementia is hospitalized each year.