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815 résultats trouvés

Profiling Cortical Excitability in ALS Using Threshold Tracking Transcranial Magnetic Stimulation and Multimodal Biomarkers

Rationale: Cortical hyperexcitability has been identified to be a potential driver of ALS pathology leading to excitotoxicity and degeneration of upper motor neurons (UMNs)in the primary motor cortex (M1) and the subsequent degeneration of lower motor neurons (LMNs) in the spinal cord.


Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2023

Defective protein translation: a causative pathway in ALS?

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43).


Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2023

Development of a shared decision-making aid for bulbar symptom management in ALS

Bulbar disease, which affects speech and swallowing functions, is considered to be one of the most debilitating aspects of ALS by patients.


Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2023

Examining vascular risk and menopausal age on women’s increased risk for AD

Two-thirds of individuals suffering from Alzheimer’s disease are women.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2023

Resetting Microglia Activation in Offspring Exposed to Maternal High-Fat Diet

Nutrition and diet are factors in life that contribute drastically to a person’s brain health, and overall quality of life, and high-fat diets can be considered a cause of many harmful physical and cognitive conditions.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Système nerveux central
Concours
Prix du personnel de maîtrise pour les boursiers noirs
Province
Ontario
DATE DE DÉBUT
2023

How brainstem microstructural integrity relates to decision-making biases in Alzheimer’s Disease

The exploration versus exploitation (E&E) decision making trade-off is something we experience every day.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Concours
Prix du personnel de maîtrise pour les boursiers noirs
Province
Ontario
DATE DE DÉBUT
2023

Stability-Based Biomarker Development to Identify Pathological Brain Areas Responsible for Freezing of Gait in Parkinson’s Disease

Brain stimulation involves using electrical or magnetic pulses to treat medical disorders like Parkinson’s by sending controlled pulses to the brain in order to manage patient symptoms.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2023

Intraoperative Identification of Residual Brain Tumour Using a Novel High-Resolution Ultrasound Endoscope and Integrated Neuronavigation System

20,800 North Americans die from brain cancer each year.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Le cancer
Concours
Bourse de stage de la Fondation Henry et Berenice Kaufmann pour la recherche sur le cancer du cerveau
Province
Nouvelle-Écosse
DATE DE DÉBUT
2023

Mechanisms of response and resistance to Olaparib and Durvalumab in treatment of glioblastomas and IDH-mutated astrocytomas

Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Le cancer
Concours
Bourse de stage de la Fondation Henry et Berenice Kaufmann pour la recherche sur le cancer du cerveau
Province
Ontario
DATE DE DÉBUT
2023

Mitochondrial dysfunction and vulnerability to oxidative stress in induced dopaminergic neurons derived from idiopathic Parkinson’s disease patients

Parkinson’s Disease (PD) is an age-associated movement disorders, mainly caused by the death of dopamine cells in the brain.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2023