Subventions financées

Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of developing cancer, particularly early in life.

Need for project: Choroidal tumors present clinicians with many challenges. The overlap between clinical and imaging findings combined with the difficulty of performing choroidal biopsies can create diagnostic dilemmas.

Need for project: Glioblastoma (GBM) is an incurable brain cancer that changes rapidly confounding standard diagnostic and therapeutic methods.

Need for project: Treatment of brain metastases (BrM) includes a combination of surgery and radiation therapy (RT).

Need for project: More sensitive molecular tools are needed in the field of neuro-oncology to enable early detection, more accurate diagnosis, and prediction of outcome for brain tumors.

Need for project: Gliomas are among the most malignant tumors, with very poor survival rates.

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortalityto patients.

In 2019, a team of scientists led by co-recipient Dr. Sali Farhan discovered a new genetic cause of ALS called DNAJC7.

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS.

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING.