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4 résultats trouvés

Role of neurofilament NFL depletion in TDP-43-mediated pathogenesis

This proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2024

Human inducible pluripotent stem cells (iPSC) platform

Studies of genetic disorders are limited because of the lack of appropriate tissue samples from patients.


TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurotechnologie
Province
Québec
DATE DE DÉBUT
2015

Preclinical and clinical studies with withanolides: Therapeutic effects, molecular signatures and biomarkers

One of the hallmarks of ALS is the presence of abnormal clumps inside motor neurons that contain various substances which include, in the majority of cases, something called TAR DNAbinding protein 43 (TDP-43).


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2015

Propagated protein misfolding of SOD1 in ALS: Exemplar for neurodegeneration

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement (motor neurons).


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2014