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Elucidating the basis for ubiquitination of misfolded ALS proteins by E3 ligase Enzymes

A pathologic feature in both sporadic and familial ALS patients is the presence of large neuronal inclusions enriched with misfolded proteins, including SOD1, TDP43 and FUS that are frequently modified with the small protein ubiquitin (Ub)


TYPE DE SUBVENTION
Subventions d'équipe
Province
Ontario
DATE DE DÉBUT
2023