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7 résultats trouvés

The Canadian Optogenetics and Vectorology Foundry

Optogenetics, defined as a technique where light-sensitive genes are introduced into brain cells to control their activity with light, allows researchers to precisely control nerve cell communication thereby, transforming brain research.

Projet en cours Voir le projet et les chercheurs
TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Système nerveux central
Province
Québec
DATE DE DÉBUT
2025

Designing synthetic extracellular matrices to support neurodegenerative disease modeling

We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture.

Projet en cours Voir le projet et les chercheurs
Domaine de recherche
Neurodégénérescence
Concours
CQDM - Brain Canada - Appel à projets de recherche collaborative sur le cerveau
Province
Québec
DATE DE DÉBUT
2025

The application of 3D models to assess the role of microglia in neurodegenerative disorders

Challenge: Alzheimer’s disease (AD) is characterized by a decline in cognitive function, yet it is now widely acknowledged that as the disease advances, dopaminergic neurons in the midbrain become particularly vulnerable, leading to non-cognitive symptoms such as motor dysfunction.

Projet en cours Voir le projet et les chercheurs
TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurodégénérescence
Concours
CQDM - Brain Canada - Quantum Leap
Province
Québec
DATE DE DÉBUT
2024

Modeling ALS progression by applying neuroinformatics to a novel in vitro human 3D tri-culture model of the disease

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which the motor neurons degenerate, leading to symptoms of muscle weakness and progressive paralysis, resulting in the death of patients from respiratory failure.

Projet en cours Voir le projet et les chercheurs
TYPE DE SUBVENTION
Subventions d'équipe
Province
Québec
DATE DE DÉBUT
2023

Development of a high throughput 3D microphysiologicalplatform for rapid automated assessment of human brain organoids response to drugs targeting neurological disorders

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common and devastating neurological diseases, with over 750,000 AD patients and over 100,000 PD patients in Canada.

Projet terminé Voir le projet et les chercheurs
TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurodégénérescence
Concours
CQDM - Brain Canada - Quantum Leap
Province
Québec
DATE DE DÉBUT
2020

Canadian Optogenetics and Vectorology Foundry

Optogenetics is a relatively new science subdomain that is revolutionizing brain research with great promises for therapeutics.

Projet en cours Voir le projet et les chercheurs
TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurotechnologie
Province
Québec
DATE DE DÉBUT
2020

A Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65.

Projet terminé Voir le projet et les chercheurs
TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurodégénérescence
Concours
CQDM - Brain Canada - Pleins feux sur le cerveau
Province
Québec
DATE DE DÉBUT
2016