Travaux subventionnés

Les facteurs de transcription des familles ATF4 et P53 dans la régulation de la morts des cellules neuronales

Aperçu du projet

Stroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Brain cell death following stroke leads to the loss of brain controlled functions such as speech and locomotion. Unfortunately, the factors that control brain cell death during stroke have not been identified. The overall objective of this research project is to identify the factors within brain cells that determine whether they will live or die following a stroke. Dr. Cregan and his team have identified pro-death factors that are activated during brain ischemia(stroke) and in this research project they will determine whether blocking these factors protects brain cells in stroke. They have developed models to mimic stroke conditions in isolated brain cells and mice. They will use drugs and genetic approaches to block the function of potential pro-death factors and determine whether this prevents the brain cells from dying during stroke conditions. Their research is directly aimed at identifying those factors that are involved in regulating brain cell death in stroke. Their research could lead to the identification of novel drug targets to reduce brain damage and minimize functional deficits in individuals affected by stroke.

Chef d'équipe

Sean Cregan , University of Western Ontario

Partenaire et Donateurs

Heart and Stroke Foundation

Projet terminé

Les facteurs de transcription des familles ATF4 et P53 dans la régulation de la morts des cellules neuronales

Type de programme
Team grants
Domaine de recherche
Accident vasculaire cérébral et lésion cérébrale
Disease Area
Stroke
Compétition
La Fondation des maladies du cœur et de l’AVC Subventions de recherche
Province
Ontario
Date de Début
2015
Montant total du financement
$256,200
Contribution Santé Canada
$128,100