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Les facteurs de transcription des familles ATF4 et P53 dans la régulation de la morts des cellules neuronales

Aperçu du projet

Stroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Brain cell death following stroke leads to the loss of brain controlled functions such as speech and locomotion. Unfortunately, the factors that control brain cell death during stroke have not been identified. The overall objective of this research project is to identify the factors within brain cells that determine whether they will live or die following a stroke. Dr. Cregan and his team have identified pro-death factors that are activated during brain ischemia(stroke) and in this research project they will determine whether blocking these factors protects brain cells in stroke. They have developed models to mimic stroke conditions in isolated brain cells and mice. They will use drugs and genetic approaches to block the function of potential pro-death factors and determine whether this prevents the brain cells from dying during stroke conditions. Their research is directly aimed at identifying those factors that are involved in regulating brain cell death in stroke. Their research could lead to the identification of novel drug targets to reduce brain damage and minimize functional deficits in individuals affected by stroke.

Chef d'équipe

Sean Cregan , University of Western Ontario

Partenaire et Donateurs

Heart and Stroke Foundation

Projet en cours

Les facteurs de transcription des familles ATF4 et P53 dans la régulation de la morts des cellules neuronales

  • Type de programme

    Team grants

  • Domaine de recherche

    Accident vasculaire cérébral et lésion cérébrale

  • Disease Area

    Stroke

  • Compétition

    Heart and Stroke Foundation Grant-in-Aid

  • Province

    Ontario

  • Date de Début

    2015

  • Montant total du financement

    $256,200

  • Contribution Santé Canada

    $128,100