Directory of funded grants

Therapeutic Targeting of GDF15 to Treat Anxiety in Diabetes

Does impaired brain insulin action underlie the shared risk of depression and diabetes? A neuroimaging clinical trial

DIgital markers of Social Cognition for diagnosis & pRognosis in Neurodegeneration (DISCeRN)

Project Overview

Impairments in social cognition (SC), such as difficulties in understanding emotions, social cues, and maintaining meaningful interactions, are key contributors to the loss of social inclusion and quality of life in individuals with neurodegenerative diseases (ND). Current clinical approaches related to SC fail to capture the dynamic nature of social…

New function for DEPTOR tyrosine 289 phosphorylation in glioma metabolism 

Project Overview

Deregulation of brain cell metabolism is commonly observed in low-grade brain cancers. Although the precise molecular mechanisms remain ill define, it is now clear that brain cancer cell often harbor altered metabolic function that promotes cell proliferation and survival. Recent evidence shows that metabolic imbalance can be an early event…

Investigating the role of L-glucose as a therapy and [18F]fluoro-deoxy-L-glucose as a diagnostic for glioblastoma

Project Overview

Using the mirror image of body’s main sugar glucose (so-called L-glucose), we plan to hijack the sugar addiction of glioblastoma (GBM) as a therapeutic target. To assessthe behavior of the unnatural form of glucose in living brain tumors, we have created a radioactively tagged L-glucose that wasfound to selective enter…