731 results found
Dysregulation of integrated stress response (ISR) pathway in Fragile X syndrome and autism
Project Overview
Mr. Hooshmandi's research will examine the hypothesis that reduced phosphorylation of eIF2α excessively stimulates general translation in Fmr1 KO mice during brain development, contributing to the pathophysiology of Fragile X syndrome (FXS) and potentially of other forms of autism. They propose three main aims in this study as follows: (1)…
Project Ongoing
See the project and researchersSex differences in exercise efficacy: Possible role of BDNF and stress axis
Project Overview
Research suggests that exercise can help improve brain health and decrease the risk of dementia, but there is variation in the benefit of different exercise interventions. Cindy Barha, Ph.D. and colleagues hypothesize that male and female brains may respond in different ways to different types of exercise such as aerobic…
Project Complete
See the project and researchersTranslating research into practice: Investigating the impact of Alzheimer’s disease diagnostics in Canada
Project Overview
Alzheimer’s disease causes progressive neurological decline and substantially decreases the quality of life of the individuals with the disease and their caregivers. Today, there are over half a million Canadians living with Alzheimer’s disease or a related form of dementia, directly costing Canada $10.4 billion a year. With a rapidly…
Project Ongoing
See the project and researchersStroke Recovery in Motion
Project Overview
One in six people worldwide will experience a stroke in their lifetime. One third of these people are left permanently disabled. In 2013, at least 405,000 Canadians were living with long-term stroke disability and this number is projected to increase to 726,000 over the next 20 years. Advances in acute…
Project Ongoing
See the project and researchersToward exercise as medicine for adolescents with bipolar disorder
Project Overview
This project focuses on improving aerobic fitness (AF) among adolescents with bipolar disorder (BD). BD affects 2-5% of adolescents and is the 4th most disabling medical condition among adolescents worldwide. Even with treatment, adolescents with BD spend over half of the time with mood symptoms that impair quality of life.…