Directory of funded grants

Filter by

774 results found

Decoding the RNA stability programs that determine cell identity and function in human brain and neurodegenerative disorders

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Azrieli Foundation – Brain Canada Early-Career Capacity Building grants

  • Province

    Québec

  • Start Date

    2019

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s. Similarly, Alzheimer’s disease appears to turn on hundreds of genes that are normally inactive in the…

Project Complete

See the project and researchers

The role of cortical inhibitory cells in human epilepsy

  • Grant Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Epilepsy

  • Competition

    Azrieli Foundation – Brain Canada Early-Career Capacity Building grants

  • Province

    Québec

  • Start Date

    2019

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Epilepsy is a debilitating neurological disorder that affects up to one percent of the world’s population. A third of epileptic patients suffer from drug-resistant form of the disease for which brain surgical intervention is often necessary. The current scientific challenge is twofold: first to advance our understanding of the biological…

Project Ongoing

See the project and researchers

Detection of misfolded TDP-43 in CSF of ALS cases: Diagnostic potential of confirmation-specific antibodies

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Ontario

  • Start Date

    2018

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms. One of the hallmarks of ALS for 97 per cent of cases is the accumulation of misfolded TDP-43…

Project Ongoing

See the project and researchers

Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $30,692

  • Health Canada Contribution

    $15,346

Project Overview

A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis. He then tested them with a battery of potential treatments to see if they could find one that would have a positive effect on motor neuron…

Project Complete

See the project and researchers

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2018

  • Province

    Québec

  • Start Date

    2018

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract. Other specialized neurons inhibit these signals, allowing muscles to relax. When this inhibitory process does not occur, motor neurons become overexcited, a hallmark feature of ALS before symptoms appear, particularly in the upper…

Project Ongoing

See the project and researchers