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676 results found

Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    BC Alzheimer's Research Award Program

  • Province

    British Columbia

  • Start Date

    2015

  • Total Grant Amount

    $1,406,191

  • Health Canada Contribution

    $703,096

Project Overview

A treatment or prevention of Alzheimer's disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. However, there are many different subtypes of amyloid-beta oligomers and the specific…

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Locally produced brain insulin in memory and Alzheimer’s disease: A multi-disciplinary approach to a key question

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    BC Alzheimer's Research Award Program

  • Province

    British Columbia

  • Start Date

    2015

  • Total Grant Amount

    $987,000

  • Health Canada Contribution

    $493,500

Project Overview

One percent of Alzheimer’s disease is the early-onset type that runs in families. Extensive studies of these ultra-rare forms of Alzheimer’s disease have revealed the genes that cause them. On the other hand, the most common forms of Alzheimer’s disease are surprisingly understudied and poorly understood at the level required…

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Distinct neuro-immune interactions drive sex differences  in chronic pain

  • Grant Type

    Team grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    2014 MIRI Team Grants

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $2,294,000

  • Health Canada Contribution

    $1,147,000

Project Overview

One of the most important advances in our understanding of chronic pain over the last decade or so is the realization that neurons are not the only cells in the central nervous system participating in the processing of pain signals. Immune-like "glial" cells (especially microglia and astrocytes), thought previously to…

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Neurobiological correlates of TMS

  • Grant Type

    Team grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    2014 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $865,517

  • Health Canada Contribution

    $432,759

Project Overview

Noninvasive brain stimulation is gaining acceptance as an alternate therapy for an increasing number of disorders, including major depression, schizophrenia, stroke and Parkinson’s disease. A form of noninvasive brain stimulation called transcranial magnetic stimulation (TMS) is less invasive and safer as compared to other brain stimulation therapies; however, lack of…

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Canadian rTMS Treatment and Biomarker Network in Depression (CARTBIND) Trial

  • Grant Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    2014 MIRI Team Grants

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $1,387,500

  • Health Canada Contribution

    $693,750

Project Overview

Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for patients with depression who have not responded to antidepressant medications. rTMS involves stimulating the brain with a series of magnetic pulses delivered through a hand-held magnetic coil. Treatment duration is about 40 min and about 8-10 treatments per day can…

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