737 results found
Synaptic inhibition in the motor cortex of an ALS mouse model
Project Overview
ALS is a disease characterized by degeneration of both upper and lower motor neurons. Upper motor neurons are located in a region of the brain called the motor cortex and have been far less extensively studied than lower motor neurons in the spinal cord. One of the earliest detectable abnormalities…
Project Complete
See the project and researchersCharacterizing the C9ORF72 protein interactome for identifying novel pathogenic pathways in ALS
Project Overview
In late 2011, a landmark discovery was made which identified that abnormalities (mutation) in a gene called C9ORF72 were responsible for the highest percentage of hereditary ALS and frontotemporal dementia cases. Since then, a lot of work has been done to understand how these mutations cause disease. In particular, researchers…
Project Complete
See the project and researchersInvestigation of the innate immune system and motor neuron degeneration in genetic models of ALS
Project Overview
In recent years, it was discovered that a microscopic worm called C. elegans could mimic some of the aspects of human ALS when they were engineered to have abnormal (mutant) genes that cause the disease. Not only do they have motor neuron degeneration like humans, but the worms experience paralysis.…
Project Complete
See the project and researchersUse of bone marrow cells to deliver single chain antibodies in ALS
Project Overview
This project will use cells found in bone marrow as a potential means of delivering treatments to the diseased area in brain and spinal cord. One of the biggest hurdles in treating ALS is that even if something was developed to slow down or stop the disease, the brain and…
Project Complete
See the project and researchersEpigenetic mechanisms underlying dendritic atrophy in ALS
Project Overview
Motor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree called dendrites that receive information to transmit. The middle part of the neuron is called the cell body where the majority of the life processes occur and the bottom…