720 results found
Mechanisms of response and resistance to Olaparib and Durvalumab in treatment of glioblastomas and IDH-mutated astrocytomas
Project Overview
Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. These tumors have genetic changes that affect their ability to repair DNA. Recent research has discovered that a combination of two drugs, Olaparib and Durvalumab, could be effective in treating these tumors. Olaparib blocks a…
Project Ongoing
See the project and researchersLeveraging proximity interactomics to identify therapeutically targetable RNA-binding proteins in G4C2 repeat-driven ALS
Project Overview
Amyotrophic lateral sclerosis (ALS) is a progressive disease that causes loss of control over muscles and leads to death quickly after diagnosis. It remains incurable, with a subtype of ALS being commonly associated with a specific genetic mutation that causes a toxic RNA molecule to be produced. This repeat-containing RNA…
Project Ongoing
See the project and researchersInvestigating cerebellar Pathology in a zebrafish C9orf72 ALS model
Project Overview
Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by degeneration of specific neurons called “Motor neurons” that control the movement of our muscles. We are particularly interested in a specific gene called C9ORF72, which is found to be mutated in most of the ALS cases.…
Project Ongoing
See the project and researchersLongitudinal Neurocognitive Trajectories in Perinatal Arterial Ischemic Stroke
Project Overview
The highest lifetime risk of stroke is the week surrounding birth, with perinatal arterial ischemic stroke (AIS) the most common stroke subtype during this period. Perinatal AIS is an acquired brain injury resulting in cerebrovascular insult to the developing brain; however, to date, there has been no longitudinal research to…
Project Ongoing
See the project and researchersMechanisms of Cognitive Impairment in Children Treated for Brain Tumors
Project Overview
In developed countries, brain tumors are the leading cause of disability and death among children. Treatment advances have improved survival rates, but survival comes at a cost for pediatric brain tumor survivors. Surgery and cranial radiotherapy are needed for cure but are both damaging to brain tissue – especially white…