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Cholinergic & noradrenergic contributions to presymptomatic AD progression
Project Overview
The development of approaches to aid early detection of the transition from healthy aging to mild cognitive impairment and Alzheimer’s disease (AD) is critically important for developing targeted strategies to halt or slow disease progression. Post-mortem studies have identified AD-related brain changes years and even decades before the age of…
Project Ongoing
See the project and researchersSerotonin circuit dysregulation in Alzheimer’s Disease
Project Overview
The early and severe loss of serotonin neurons along with the neuroprotective effects of SSRIs in Alzheimer’s Disease (AD) strongly implicates the serotonin system in disease pathology. Yet, mechanisms underlying the vulnerability and contribution of the serotonin system to AD progression remain unknown. Serotonergic impairment early in disease process is…
Project Ongoing
See the project and researchersElectrophysiological measures of proteinopathy in asymptomatic older adults
Project Overview
Our project proposes the development and first-step validation of a new, noninvasive mapping procedure of proteinopathy in asymptomatic older adults. Our approach consists in applying recent advances in magnetoencephalography (MEG) methods that yield the neurophysiological fingerprint of each individual from short recordings of task-free brain activity. We will test the…
Project Ongoing
See the project and researchersDetecting Behaviours of Risk in Nursing Homes using Deep Learning
Project Overview
Many people with dementia (PwD) live in nursing homes, which often suffer from a lack of skilled staff to support and monitor the safety of residents. Behavioural and psychological symptoms of dementia are commonly seen as a result of this lack of support and can be associated with risk for…
Project Ongoing
See the project and researchersFrom Space to Memory Under Pathological Tau
Project Overview
Among the earliest signs of preclinical Alzheimer’s disease (AD) are navigation impairments and the presence of abnormal Tau (aTau) proteins in the entorhinal cortex (EC), a brain region that represents space and movement. As AD progresses aTau spreads to the subiculum (Sub), a key region for memory encoding and retrieval.…