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Funded Grants

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From Space to Memory Under Pathological Tau

Project Overview

Among the earliest signs of preclinical Alzheimer’s disease (AD) are navigation impairments and the presence of abnormal Tau (aTau) proteins in the entorhinal cortex (EC), a brain region that represents space and movement. As AD progresses aTau spreads to the subiculum (Sub), a key region for memory encoding and retrieval. At present it is not known how navigation impairments in preclinical AD progress to the episodic memory loss seen in clinical AD. We hypothesize that the spread of EC aTau to Sub underlies the progress from navigation impairments to wider memory deficits. We will inject Cre-dependent mutant Tau into EC using a mouse line that limits Cre expression to the EC layer 3 to best approximate the aTau conditions of preclinical AD in humans. We will

  1. assess the spread of aTau from the EC to Sub
  2. determine if aTau disrupts spatial/mnemonic processing at the cellular and behavioural levels, and
  3. attempt to rescue any impairments with circuit specific stimulation.

Principal Investigator

James Carmichael , Douglas Hospital Research Center

Partners and Donors

Alzheimer's Association

Project Ongoing

From Space to Memory Under Pathological Tau

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $196,985

  • Health Canada Contribution

    $85,725

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Please note all online donations will receive an electronic tax receipt, issued by Brain Canada Foundation.

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Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien'kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations. We honour and pay respect to elders past, present and emerging, and dedicate ourselves to moving forward in the spirit of partnership, collaboration, and reconciliation. In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues.

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