720 results found
Molecular and behavioural assessment of a potential fetal Cannabis spectrum disorder in the rat
Project Overview
Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. There is a recent and growing false belief that Cannabis can reduce nausea during pregnancy without harmful side effects on the fetus. This belief is not based in scientific research, of which there is very…
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See the project and researchersRelating hippocampal pathways to human learning
Project Overview
The human experience is marked by constant learning. Moments of contention, when new experiences conflict with prior knowledge, often lead to the most meaningful learning. How do we successfully navigate these moments and gain new knowledge? In the current project, we aim to answer this question by characterizing (1) how…
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See the project and researchersThe endocannabinoid system: a master regulator of brain and gut health in mood disorders
Project Overview
Depression will affect 1 out of 5 individuals in their lifetime. Antidepressant treatments are not effective for 30-50% patients, only 30% completely remit and do not suffer from another depressive episode, suggesting that current therapies do not address important biological mechanisms involved such as neurovascular dysfunction or inflammation, which are…
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See the project and researchersInvestigation of neuroinflammation and microglial subtypes associated with ALS
Project Overview
The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is neuronal death. Several decades of basic research have focused on investigating the mechanisms underlying neuronal death and dysfunction. Accumulating studies showed that neuroinflammation is correlated with disease progression, suggesting…
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See the project and researchersNeuroprosthetic-mediated rehabilitation of autonomic function after spinal cord injury
Project Overview
Spinal cord injury (SCI) is a devastating medical condition that forever changes the trajectory of life. It is also costly to the health care system, similar to traumatic brain injury or Alzheimer’s. Perhaps surprisingly, people with SCI report autonomic (i.e., automatic/unconscious) issues such as cardiovascular dysfunction as a more important…