738 results found
The endocannabinoid system: a master regulator of brain and gut health in mood disorders
Project Overview
Depression will affect 1 out of 5 individuals in their lifetime. Antidepressant treatments are not effective for 30-50% patients, only 30% completely remit and do not suffer from another depressive episode, suggesting that current therapies do not address important biological mechanisms involved such as neurovascular dysfunction or inflammation, which are…
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See the project and researchersInvestigation of neuroinflammation and microglial subtypes associated with ALS
Project Overview
The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is neuronal death. Several decades of basic research have focused on investigating the mechanisms underlying neuronal death and dysfunction. Accumulating studies showed that neuroinflammation is correlated with disease progression, suggesting…
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See the project and researchersNeuroprosthetic-mediated rehabilitation of autonomic function after spinal cord injury
Project Overview
Spinal cord injury (SCI) is a devastating medical condition that forever changes the trajectory of life. It is also costly to the health care system, similar to traumatic brain injury or Alzheimer’s. Perhaps surprisingly, people with SCI report autonomic (i.e., automatic/unconscious) issues such as cardiovascular dysfunction as a more important…
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See the project and researchersMapping neuronal circuits using a novel transsynaptic labelling approach
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The brain is more than the sum of its parts. Truly understanding the brain's most intricate properties requires both a list of its individual parts, that is a census of the types of neurons it contains, and a map of how these parts are interconnected to form neural circuits. Hundreds…
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See the project and researchersTanycytic structural plasticity in circumventricular organs underlies homeostatic brain-body communication
Project Overview
Metabolic syndrome is a group of risk factors (obesity, hypertension, high fasting blood sugar, and high levels of triglycerides) that increase the risk of type 2 diabetes and cardiovascular diseases. Over 20% of adult Canadians suffer from metabolic syndrome (40% in adults over 60 years old), and effective treatments are…