721 results found
Nociceptor neurons control cancer immunosurveillance
Project Overview
Dr. Talbot studies the dialogue between the nervous and immune systems. It is well demonstrated that pain and itch are common features of various cancers, and that cancer cells actively secrete factors promoting neuronal infiltration of tumors. Recent data suggests that experimentally stopping the electrical signals of tumor infiltrating neurons…
Project Complete
See the project and researchersMapping the cellular origins of circuit vulnerability in neurodevelopmental disorders
Project Overview
The brain is an incredibly complex organ. Much of the brain's complexity may be attributed to the circuitry that resides within. Synaptic connections are the key units of information transduction and therefore and therefore an increasing amount of research focus has centered on understanding how they normally function and how…
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See the project and researchersDecoding the RNA stability programs that determine cell identity and function in human brain and neurodegenerative disorders
Project Overview
The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s. Similarly, Alzheimer’s disease appears to turn on hundreds of genes that are normally inactive in the…
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See the project and researchersThe role of cortical inhibitory cells in human epilepsy
Project Overview
Epilepsy is a debilitating neurological disorder that affects up to one percent of the world’s population. A third of epileptic patients suffer from drug-resistant form of the disease for which brain surgical intervention is often necessary. The current scientific challenge is twofold: first to advance our understanding of the biological…
Project Ongoing
See the project and researchersDetection of misfolded TDP-43 in CSF of ALS cases: Diagnostic potential of confirmation-specific antibodies
Project Overview
A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms. One of the hallmarks of ALS for 97 per cent of cases is the accumulation of misfolded TDP-43…