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A pilot randomized-controlled trial evaluating the efficacy of a Live-Online Mindfulness-Based Intervention for Children with Juvenile Idiopathic Arthritis and their Families’: The Making Mindfulness Matter© in Children with Juvenile Idiopathic Arthritis Study.
https://braincanada.ca/fr/subventions-financées/a-pilot-randomized-controlled-trial-evaluating-the-efficacy-of-a-live-online-mindfulness-based-intervention-for-children-with-juvenile-idiopathic-arthritis-and-their-families-the-making-mindfulness-matter-in-children-with-juvenile-idiopathic-arthritis-studyThe goal of our research study is to better understand the comorbidity of mental health and disease in a sample of children with juvenile idiopathic arthritis (JIA) and their primary caregiver(s). Project Overview The goal of our research study is to better understand the comorbidity of mental...
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A Pilot Randomized Trial of a Digital App, WhatMatters to enable Person-Centred Care
https://braincanada.ca/fr/subventions-financées/a-pilot-randomized-trial-of-a-digital-app-whatmatters-to-enable-person-centred-carePerson-centred care is vital for dementia patients in hospitals to prevent stress-induced behaviors. Project Overview Person-centred care is vital for dementia patients in hospitals to prevent stress-induced behaviors. My team has developed WhatMatters, an app that allows family members to remotely...
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A prodepressive dopamine receptor complex in brain mediates sex differences in depression and anxiety: validation and strategies for drug discovery
https://braincanada.ca/fr/subventions-financées/a-prodepressive-dopamine-receptor-complex-in-brain-mediates-sex-differences-in-depression-and-anxiety-validation-and-strategies-for-drug-discoveryMajor depression is common, highly prevalent, potentially lethal, affecting 10% of individuals with significant increase between 2015-2020, and 2-3-fold higher incidence in women compared to men. Project Overview Major depression is common, highly prevalent, potentially lethal, affecting 10% of...
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A Randomized Controlled Trial of Pimozide in Subjects with ALS
https://braincanada.ca/fr/subventions-financées/a-randomized-controlled-trial-of-pimozide-in-subjects-with-alsThis project is a Phase II study involving 100 participants across 8 ALS clinics across Canada. The trial, led by the Principal Investigator of the Canadian Neuromuscular Disease Registry (CNDR) and the Chair of the Canadian ALS Research Network (CALS) will examine whether pimozide, a drug already...
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A Randomized Sham-Controlled Trial of Accelerated Intermittent Theta Burst Stimulation for Treatment Resistant Depression
https://braincanada.ca/fr/subventions-financées/a-randomized-sham-controlled-trial-of-accelerated-intermittent-theta-burst-stimulation-for-treatment-resistant-depressionBy 2050, over 1 million Canadians will suffer from depression; many of whom will not respond to traditional antidepressant medication, known to as treatment resistant depression (TRD). Project Overview By 2050, over 1 million Canadians will suffer from depression; many of whom will not respond to...
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A research platform to study animal and human cellular models of neurological disorders
https://braincanada.ca/fr/subventions-financées/a-research-platform-to-study-animal-and-human-cellular-models-of-neurological-disordersNeurological diseases including neurodegenerative, neurodevelopmental, and psychiatric disorders are collectively one of the leading causes of disability to the Canadian population. Project Overview Neurological diseases including neurodegenerative, neurodevelopmental, and psychiatric disorders are...
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A sustainable ecosystem of care for women with traumatic brain injury following intimate partner violence: First steps.
https://braincanada.ca/fr/subventions-financées/a-sustainable-ecosystem-of-care-for-women-with-traumatic-brain-injury-following-intimate-partner-violence-first-stepsWomen victims of intimate partner violence (IPV) are at high risk of traumatic brain injury (TBI). As many as 75% are thought to have sustained a TBI, though most remain undiagnosed and untreated, but nonetheless live with its lasting effects. Project Overview Women victims of intimate partner...
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A “tipping point” neuron type driving Alzheimer’s Disease progression
https://braincanada.ca/fr/subventions-financées/a-tipping-point-neuron-type-driving-alzheimer-s-disease-progressionAlzheimer’s Disease (AD) is characterized by dysregulation of neurons involved in memory, which is believed to be caused by the production of an agent termed “amyloid beta”. Project Overview Alzheimer’s Disease (AD) is characterized by dysregulation of neurons involved in memory, which is believed...
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A unifying approach to treat multisystem proteinopathy and ALS using noninvasive novel ASO delivery
https://braincanada.ca/fr/subventions-financées/a-unifying-approach-to-treat-multisystem-proteinopathy-and-als-using-noninvasive-novel-aso-deliveryMultisystem proteinopathy (MSP) is a devastating rare disease described by a cluster of diseases that affect the brain, bone, and muscle. Project Overview Multisystem proteinopathy (MSP) is a devastating rare disease described by a cluster of diseases that affect the brain, bone, and muscle....
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A universal platform for high volume genetic modifier testing in Tauopathy
https://braincanada.ca/fr/subventions-financées/a-universal-platform-for-high-volume-genetic-modifier-testing-in-tauopathyGenetic testing shows that the Tau gene can often carry changes (DNA mutations) in people with dementia, and also in people who are not yet diagnosed with dementia. Project Overview Genetic testing shows that the Tau gene can often carry changes (DNA mutations) in people with dementia, and also in...