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A “tipping point” neuron type driving Alzheimer’s Disease progression
https://braincanada.ca/fr/subventions-financées/a-tipping-point-neuron-type-driving-alzheimer-s-disease-progressionAlzheimer’s Disease (AD) is characterized by dysregulation of neurons involved in memory, which is believed to be caused by the production of an agent termed “amyloid beta”. Project Overview Alzheimer’s Disease (AD) is characterized by dysregulation of neurons involved in memory, which is believed...
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A unifying approach to treat multisystem proteinopathy and ALS using noninvasive novel ASO delivery
https://braincanada.ca/fr/subventions-financées/a-unifying-approach-to-treat-multisystem-proteinopathy-and-als-using-noninvasive-novel-aso-deliveryMultisystem proteinopathy (MSP) is a devastating rare disease described by a cluster of diseases that affect the brain, bone, and muscle. Project Overview Multisystem proteinopathy (MSP) is a devastating rare disease described by a cluster of diseases that affect the brain, bone, and muscle....
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A universal platform for high volume genetic modifier testing in Tauopathy
https://braincanada.ca/fr/subventions-financées/a-universal-platform-for-high-volume-genetic-modifier-testing-in-tauopathyGenetic testing shows that the Tau gene can often carry changes (DNA mutations) in people with dementia, and also in people who are not yet diagnosed with dementia. Project Overview Genetic testing shows that the Tau gene can often carry changes (DNA mutations) in people with dementia, and also in...
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Aberrant tRNA function exacerbates TDP-43 misfolding and toxicity in cellular models of ALS
https://braincanada.ca/fr/subventions-financées/aberrant-trna-function-exacerbates-tdp-43-misfolding-and-toxicity-in-cellular-models-of-alsAberrant tRNA processing and function has the capacity to exacerbate misfolding of ALS-associated proteins and the ensuing toxicity. Project Overview Aberrant tRNA processing and function has the capacity to exacerbate misfolding of ALS-associated proteins and the ensuing toxicity. tRNAs mainly...
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Accelerating implementation of Canada’s first national Pediatric Pain Standard: Enhancing equitable care for children with neurodevelopmental disabilities in hospital settings
https://braincanada.ca/fr/subventions-financées/accelerating-implementation-of-canada-s-first-national-pediatric-pain-standard-enhancing-equitable-care-for-children-with-neurodevelopmental-disabilities-in-hospital-settingsCanada is a world leader in children’s pain research and effective treatments exist, yet Canadian children continue to experience undertreated and preventable pain. Project Overview Canada is a world leader in children’s pain research and effective treatments exist, yet Canadian children continue...
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Accelerating the Integration of Be EPIC-VR in Dementia Care
https://braincanada.ca/fr/subventions-financées/accelerating-the-integration-of-be-epic-vr-in-dementia-carePersonal support workers provide the most formal care to people living with dementia. Project Overview Personal support workers provide the most formal care to people living with dementia. Their formal training often does not address complex dementia-related communication impairments and responsive...
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Accelerating the Reach of the Driving and Dementia Roadmap
https://braincanada.ca/fr/subventions-financées/accelerating-the-reach-of-the-driving-and-dementia-roadmapThis project focuses on accelerating awareness about the importance of the issue of driving cessation by promoting the uptake of the Driving and Dementia Roadmap (DDR). Project Overview This project focuses on accelerating awareness about the importance of the issue of driving cessation by...
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Accélérer la recherche sur l'IA et le cerveau
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/accélérer-la-recherche-sur-l-intelligence-artificielle-et-le-cerveauAprès avoir rencontré des parlementaires à Ottawa, Brain Canada a publié un rapport de consultation pancanadien soulignant une série de possibilités d'investissement immédiat dans la recherche en IA et en neurosciences.le rapport reflète les commentaires reçus lors de huit tables rondes sur la...
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Accélérer la recherche sur la maladie d’Alzheimer
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/accélérer-la-recherche-sur-la-maladie-d-alzheimerSylvia Villeneuve, Ph. D., fait avancer la recherche sur la maladie d’Alzheimer aux quatre coins de la planète. Grâce au partage des données exhaustives recueillies auprès de patientes et patients en phase préclinique de la maladie d’Alzheimer, le référentiel et plateforme d’échange de données pour...
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Adaptive Platform Trial to Investigate VArious ThErapies in Carotid-Associated Stroke (ACTIVATE-CAS)- Pilot Phase
https://braincanada.ca/fr/subventions-financées/adaptive-platform-trial-to-investigate-various-therapies-in-carotid-associated-stroke-activate-cas-pilot-phaseCarotid disease accounts for 10% of ischemic strokes and has high rate of recurrence of up to 30%-50%(1, 2). Project Overview Carotid disease accounts for 10% of ischemic strokes and has high rate of recurrence of up to 30%-50%(1, 2). There is lack of adequate updated data on its prevalence,...