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A Novel Microfluidic Platform for Investigating Axonal Sprouting in Motor Neurons
https://braincanada.ca/fr/subventions-financées/a-novel-microfluidic-platform-for-investigating-axonal-sprouting-in-motor-neuronsMotor neurons are extremely complex cells. Not only do they have an intricate set of inner workings, but they have a long wire-like portion called an axon that connects the central nervous system to muscles called an axon. Project Overview Motor neurons are extremely complex cells. Not only do they...
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A Novel Zebrafish-Based Platform for Anticonvulsant Drug Development
https://braincanada.ca/fr/subventions-financées/a-novel-zebrafish-based-platform-for-anticonvulsant-drug-developmentEpilepsy is a common neurological condition that affects 1-2% of the population. Project Overview Epilepsy is a common neurological condition that affects 1-2% of the population. Despite dozens of anticonvulsant medications, over a third of patients remain refractory to drugs and our goal is to...
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A Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
https://braincanada.ca/fr/subventions-financées/a-patient-derived-hipsc-neuronal-platform-for-drug-discovery-in-parkinson-s-disease-and-amyotrophic-lateral-sclerosisParkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65. Project Overview Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most...
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A patient-derived iPSC platform of disease relevant cell models for biological studies
https://braincanada.ca/fr/subventions-financées/a-patient-derived-ipsc-platform-of-disease-relevant-cell-models-for-biological-studiesOne of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). Project Overview One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). These cells make it...
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A personalized medicine approach to better understand the biology of bipolar disorder
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/a-personalized-medicine-approach-to-better-understand-the-biology-of-bipolar-disorder -
A physiologic-to-tissue level approach to characterize the pathophysiology of hypoxic ischemic brain injury in humans.
https://braincanada.ca/fr/subventions-financées/a-physiologic-to-tissue-level-approach-to-characterize-the-pathophysiology-of-hypoxic-ischemic-brain-injury-in-humansDuring a cardiac arrest, when the heart stops beating, blood flow and the delivery of the oxygen to the brain stops. Project Overview During a cardiac arrest, when the heart stops beating, blood flow and the delivery of the oxygen to the brain stops. This lack of blood flow and oxygen leads to a...
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A pilot randomized-controlled trial evaluating the efficacy of a Live-Online Mindfulness-Based Intervention for Children with Juvenile Idiopathic Arthritis and their Families’: The Making Mindfulness Matter© in Children with Juvenile Idiopathic Arthritis Study.
https://braincanada.ca/fr/subventions-financées/a-pilot-randomized-controlled-trial-evaluating-the-efficacy-of-a-live-online-mindfulness-based-intervention-for-children-with-juvenile-idiopathic-arthritis-and-their-families-the-making-mindfulness-matter-in-children-with-juvenile-idiopathic-arthritis-studyThe goal of our research study is to better understand the comorbidity of mental health and disease in a sample of children with juvenile idiopathic arthritis (JIA) and their primary caregiver(s). Project Overview The goal of our research study is to better understand the comorbidity of mental...
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A Pilot Randomized Trial of a Digital App, WhatMatters to enable Person-Centred Care
https://braincanada.ca/fr/subventions-financées/a-pilot-randomized-trial-of-a-digital-app-whatmatters-to-enable-person-centred-carePerson-centred care is vital for dementia patients in hospitals to prevent stress-induced behaviors. Project Overview Person-centred care is vital for dementia patients in hospitals to prevent stress-induced behaviors. My team has developed WhatMatters, an app that allows family members to remotely...
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A prodepressive dopamine receptor complex in brain mediates sex differences in depression and anxiety: validation and strategies for drug discovery
https://braincanada.ca/fr/subventions-financées/a-prodepressive-dopamine-receptor-complex-in-brain-mediates-sex-differences-in-depression-and-anxiety-validation-and-strategies-for-drug-discoveryMajor depression is common, highly prevalent, potentially lethal, affecting 10% of individuals with significant increase between 2015-2020, and 2-3-fold higher incidence in women compared to men. Project Overview Major depression is common, highly prevalent, potentially lethal, affecting 10% of...
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A Randomized Controlled Trial of Pimozide in Subjects with ALS
https://braincanada.ca/fr/subventions-financées/a-randomized-controlled-trial-of-pimozide-in-subjects-with-alsThis project is a Phase II study involving 100 participants across 8 ALS clinics across Canada. The trial, led by the Principal Investigator of the Canadian Neuromuscular Disease Registry (CNDR) and the Chair of the Canadian ALS Research Network (CALS) will examine whether pimozide, a drug already...