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A Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
https://braincanada.ca/fr/subventions-financées/a-patient-derived-hipsc-neuronal-platform-for-drug-discovery-in-parkinson-s-disease-and-amyotrophic-lateral-sclerosisParkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65. Project Overview Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most...
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A patient-derived iPSC platform of disease relevant cell models for biological studies
https://braincanada.ca/fr/subventions-financées/a-patient-derived-ipsc-platform-of-disease-relevant-cell-models-for-biological-studiesOne of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). Project Overview One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). These cells make it...
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A physiologic-to-tissue level approach to characterize the pathophysiology of hypoxic ischemic brain injury in humans.
https://braincanada.ca/fr/subventions-financées/a-physiologic-to-tissue-level-approach-to-characterize-the-pathophysiology-of-hypoxic-ischemic-brain-injury-in-humansDuring a cardiac arrest, when the heart stops beating, blood flow and the delivery of the oxygen to the brain stops. Project Overview During a cardiac arrest, when the heart stops beating, blood flow and the delivery of the oxygen to the brain stops. This lack of blood flow and oxygen leads to a...
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A pilot randomized-controlled trial evaluating the efficacy of a Live-Online Mindfulness-Based Intervention for Children with Juvenile Idiopathic Arthritis and their Families’: The Making Mindfulness Matter© in Children with Juvenile Idiopathic Arthritis Study.
https://braincanada.ca/fr/subventions-financées/a-pilot-randomized-controlled-trial-evaluating-the-efficacy-of-a-live-online-mindfulness-based-intervention-for-children-with-juvenile-idiopathic-arthritis-and-their-families-the-making-mindfulness-matter-in-children-with-juvenile-idiopathic-arthritis-studyThe goal of our research study is to better understand the comorbidity of mental health and disease in a sample of children with juvenile idiopathic arthritis (JIA) and their primary caregiver(s). Project Overview The goal of our research study is to better understand the comorbidity of mental...
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A Pilot Randomized Trial of a Digital App, WhatMatters to enable Person-Centred Care
https://braincanada.ca/fr/subventions-financées/a-pilot-randomized-trial-of-a-digital-app-whatmatters-to-enable-person-centred-carePerson-centred care is vital for dementia patients in hospitals to prevent stress-induced behaviors. Project Overview Person-centred care is vital for dementia patients in hospitals to prevent stress-induced behaviors. My team has developed WhatMatters, an app that allows family members to remotely...
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A prodepressive dopamine receptor complex in brain mediates sex differences in depression and anxiety: validation and strategies for drug discovery
https://braincanada.ca/fr/subventions-financées/a-prodepressive-dopamine-receptor-complex-in-brain-mediates-sex-differences-in-depression-and-anxiety-validation-and-strategies-for-drug-discoveryMajor depression is common, highly prevalent, potentially lethal, affecting 10% of individuals with significant increase between 2015-2020, and 2-3-fold higher incidence in women compared to men. Project Overview Major depression is common, highly prevalent, potentially lethal, affecting 10% of...
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A Randomized Controlled Trial of Pimozide in Subjects with ALS
https://braincanada.ca/fr/subventions-financées/a-randomized-controlled-trial-of-pimozide-in-subjects-with-alsThis project is a Phase II study involving 100 participants across 8 ALS clinics across Canada. The trial, led by the Principal Investigator of the Canadian Neuromuscular Disease Registry (CNDR) and the Chair of the Canadian ALS Research Network (CALS) will examine whether pimozide, a drug already...
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A Randomized Sham-Controlled Trial of Accelerated Intermittent Theta Burst Stimulation for Treatment Resistant Depression
https://braincanada.ca/fr/subventions-financées/a-randomized-sham-controlled-trial-of-accelerated-intermittent-theta-burst-stimulation-for-treatment-resistant-depressionBy 2050, over 1 million Canadians will suffer from depression; many of whom will not respond to traditional antidepressant medication, known to as treatment resistant depression (TRD). Project Overview By 2050, over 1 million Canadians will suffer from depression; many of whom will not respond to...
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A research platform to study animal and human cellular models of neurological disorders
https://braincanada.ca/fr/subventions-financées/a-research-platform-to-study-animal-and-human-cellular-models-of-neurological-disordersNeurological diseases including neurodegenerative, neurodevelopmental, and psychiatric disorders are collectively one of the leading causes of disability to the Canadian population. Project Overview Neurological diseases including neurodegenerative, neurodevelopmental, and psychiatric disorders are...
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A sustainable ecosystem of care for women with traumatic brain injury following intimate partner violence: First steps.
https://braincanada.ca/fr/subventions-financées/a-sustainable-ecosystem-of-care-for-women-with-traumatic-brain-injury-following-intimate-partner-violence-first-stepsWomen victims of intimate partner violence (IPV) are at high risk of traumatic brain injury (TBI). As many as 75% are thought to have sustained a TBI, though most remain undiagnosed and untreated, but nonetheless live with its lasting effects. Project Overview Women victims of intimate partner...
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