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A combined in-vivo ex-vivo approach to investigate imaging biomarkers in ALS diagnosis and aetiology
https://braincanada.ca/fr/subventions-financées/a-combined-in-vivo-ex-vivo-approach-to-investigate-imaging-biomarkers-in-als-diagnosis-and-aetiologyAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately death. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor...
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A critical examination of family caregivers’ views on and experiences with medical assistance in dying
https://braincanada.ca/fr/subventions-financées/a-critical-examination-of-family-caregivers-views-on-and-experiences-with-medical-assistance-in-dyingIndividuals with an incurable condition marked by decline and intolerable suffering and where death is reasonably foreseeable, as with dementia, now have access to medical assistance in dying (MAID). Project Overview Individuals with an incurable condition marked by decline and intolerable...
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A Drug Screening Assay to Reduce LINGO-1 Amounts in Neurons
https://braincanada.ca/fr/subventions-financées/a-drug-screening-assay-to-reduce-lingo-1-amounts-in-neuronsThe LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. Project Overview The LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. LINGO-1 is a transmembrane protein that negatively regulates neuronal survival and...
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A Drug Screening Platform to Increase Protein Expression Levels for Treatment of Neurological Disorders
https://braincanada.ca/fr/subventions-financées/a-drug-screening-platform-to-increase-protein-expression-levels-for-treatment-of-neurological-disordersNeurological and psychiatric diseases and disorders affect more than half the population. Project Overview Neurological and psychiatric diseases and disorders affect more than half the population. These disorders of the nervous system can span a range of illnesses, including generalized anxiety...
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A Human System to study Immune-Ependymal Cell Relationships
https://braincanada.ca/fr/subventions-financées/a-human-system-to-study-immune-ependymal-cell-relationshipsEpendymal cells are a largely understudied barrier cell type in the brain that provide a wall between brain tissue and brain fluid (cerebral spinal fluid, CSF), playing an important role in regulating fluid balance. Project Overview Ependymal cells are a largely understudied barrier cell type in...
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A machine-learning approach to personalized risk prediction for recurrent ischemic stroke using population-level event data and routine brain imaging
https://braincanada.ca/fr/subventions-financées/a-machine-learning-approach-to-personalized-risk-prediction-for-recurrent-ischemic-stroke-using-population-level-event-data-and-routine-brain-imagingIschemic stroke, caused by a blood clot in the brain, is a leading cause of death, disability, and dementia. Project Overview Ischemic stroke, caused by a blood clot in the brain, is a leading cause of death, disability, and dementia. One in four of these strokes happens in patients who already had...
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A mixed-methods evaluation of a dance therapy intervention for students seeking on-campus mental health services
https://braincanada.ca/fr/subventions-financées/a-mixed-methods-evaluation-of-a-dance-therapy-intervention-for-students-seeking-on-campus-mental-health-servicesDecades of dance research have demonstrated the positive benefits of dance in terms of improving quality of life and reducing symptomatology for diverse groups of participants. Project Overview Decades of dance research have demonstrated the positive benefits of dance in terms of improving quality...
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A multi-centre, prospective, randomized, open-label, blinded endpoint (PROBE) controlled trial comparing acute cervical internal carotid artery stenting to no stenting during endovascular thrombectomy for anterior circulation stroke due to acute tandem occlusion: Endovascular Acute Stroke Intervention – Tandem OCclusion trial (EASI-TOC)
https://braincanada.ca/fr/subventions-financées/a-multi-centre-prospective-randomized-open-label-blinded-endpoint-probe-controlled-trial-comparing-acute-cervical-internal-carotid-artery-stenting-to-no-stenting-during-endovascular-thrombectomy-for-anterior-circulation-stroke-due-to-acute-tandem-occlusion-endovascular-acute-stroke-intervention-tandem-occlusion-trial-easi-tocIschemic stroke occurs when a person suffers a sudden blockage of an artery in their brain. Project Overview Ischemic stroke occurs when a person suffers a sudden blockage of an artery in their brain. Severe strokes caused by blockage of large brain arteries are treated with a very effective...
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A multi-methods multi-site study of end-of-life care in individuals with ALS: goal concordance and caregiver perceptions
https://braincanada.ca/fr/subventions-financées/a-multi-methods-multi-site-study-of-end-of-life-care-in-individuals-with-als-goal-concordance-and-caregiver-perceptionsAmyotrophic lateral sclerosis (ALS) is a terminal disease of nerves and muscles. From the time of symptom onset, people with ALS live about 3-5 years. Project Overview Amyotrophic lateral sclerosis (ALS) is a terminal disease of nerves and muscles. From the time of symptom onset, people with ALS...
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A multi-platform approach to the functional assessment of ASD gene variants
https://braincanada.ca/fr/subventions-financées/a-multi-platform-approach-to-the-functional-assessment-of-asd-gene-variantsThe high and potentially increasing prevalence of Autism Spectrum Disorder (ASD) is taking a significant emotional and economic toll on patients, their families and Canadian society. Project Overview The high and potentially increasing prevalence of Autism Spectrum Disorder (ASD) is taking a...
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