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Stroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Project Overview Stroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Brain cell death following stroke...

The role of microglia in spinal cord injury (SCI) has remained obscure for decades. Project Overview The role of microglia in spinal cord injury (SCI) has remained obscure for decades. Microglia, the resident immune cells of the brain and spinal cord, were historically perceived as harmful to...

Mitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). Project Overview Mitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). It is important to understand how the regulation of mitochondria is impaired...

This proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease. Project Overview his proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse...

Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. Project Overview Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. However, the mechanisms underlying the...

Developmental signaling pathways are known to play important roles in normal neural stem cell (NSC) dynamics and can significantly alter the development of gliomas, highly aggressive brain tumours that arise from NSC-like tumour-initiating cells (TIC). Project Overview Developmental signaling...

“La bonne intervention, au bon moment, pour le bon enfant”. Project Overview “La bonne intervention, au bon moment, pour le bon enfant”. Le bien-être et l’amélioration des capacités adaptatives des enfants ayant des troubles du neurodéveloppement nécessitent des interventions personnalisées dans le...

Brain Canada et Parkinson Canada sont heureux d'annoncer les gagnants du défi de données du Réseau ouvert canadien Parkinson (ROCP). Cette opportunité de subvention de recherche, lancée et financée en partenariat entre Parkinson Canada et Brain Canada, a été conçue pour accélérer la recherche sur la...

Many childhood disorders, such as Autism Spectrum Disorder (ASD) or Fragile X Syndrome (FXS), are a result of abnormal growth and connections throughout the brain, rather than being caused by some specific pathology, such as a tumour. Project Overview Many childhood disorders, such as Autism...

Les Instituts de recherche en santé du Canada (IRSC) sont heureux d’annoncer que la subvention Centre de mobilisation des connaissances issues de la recherche canadienne sur la santé cérébrale et les troubles cognitifs associés au vieillissement, offerte par les IRSC en partenariat avec la Fondation...