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Periodontal disease has links with Alzheimer’s disease. Project Overview Periodontal disease has links with Alzheimer’s disease. The bacterium Porphyromonas gingivalis plays a major role in gum disease and has been associated with Alzheimer’s disease. We have identified a small protein, produced by...

A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Project Overview A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the...

Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD) are devastating diseases in which a protein called TDP-43 ends up in the wrong part of the cell, disrupting its normal role in managing RNA. Project Overview Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD)...

Glioblastoma multiforme (GBM) the most common form of brain cancer in adults with very low survival of only 15 months with less than 5% of patients surviving more than 5 years. Surgery, chemotherapy, and radiation are the treatments currently used but recurrence is very common, often with tumors...

Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Project Overview Background Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Balancing these excitatory and inhibitory...

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions. Project Overview Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions. However, even for genetically defined components of...

Alzheimer’s Disease (AD) affects many people and leads to memory loss and cognitive decline. It is linked to brain inflammation and changes in proteins like GFAP, which is usually found in support cells called astrocytes. Project Overview Alzheimer’s Disease (AD) affects many people and leads to...

Spinal cord injury leads to permanent and severe paralysis and loss of sensation. Project Overview Spinal cord injury leads to permanent and severe paralysis and loss of sensation. The principal reason for this is that nerve cells connecting the brain with the rest of the body lose the capacity to...

The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. Project Overview The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells...

Individuals with or at increased risk of Alzheimer’s disease (AD) have an altered community of microbes(microbiome) within the intestinal tract. Project Overview Individuals with or at increased risk of Alzheimer’s disease (AD) have an altered community of microbes(microbiome) within the intestinal...