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Challenge: Alzheimer’s disease (AD) is characterized by a decline in cognitive function, yet it is now widely acknowledged that as the disease advances, dopaminergic neurons in the midbrain become particularly vulnerable, leading to non-cognitive symptoms such as motor dysfunction. Project...

Current preclinical models to address neurological disorders fail to accurately portray human physiology. Project Overview Current preclinical models to address neurological disorders fail to accurately portray human physiology. First, traditional tissue culture in which neuronal cells are grown in...

People with dementia are at a high risk for falls which are a leading cause of injury and can contribute to loss of independence and quality of life. Project Overview People with dementia are at a high risk for falls which are a leading cause of injury and can contribute to loss of independence and...

The recent breakthrough technology of single-cell genomics has vastly improved our capacity to understand how the trillions of cells in our body develop and work together to make us human. Project Overview The recent breakthrough technology of single-cell genomics has vastly improved our capacity...

By the time a person receives a diagnosis of Alzheimer’s disease (AD) dementia, brain atrophy is such that memory impairments are irreversible. Project Overview By the time a person receives a diagnosis of Alzheimer’s disease (AD) dementia, brain atrophy is such that memory impairments are...

The neonatal brain is exquisitely vulnerable to the biological consequences of prematurity, birth asphyxia and congenital heart defects. Project Overview The neonatal brain is exquisitely vulnerable to the biological consequences of prematurity, birth asphyxia and congenital heart defects. Brain...

A new national initiative funded by the Canadian Cancer Society, the Canadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT), is bringing together researchers, clinicians, policymakers, and people living with advanced cancer to explore the potential of psychedelic-assisted therapy as a...

Dr. De Koninck studies the persistent changes in spinal cord function that occur after nervous system injury that lead to chronic pain. Project Overview Dr. De Koninck studies the persistent changes in spinal cord function that occur after nervous system injury that lead to chronic pain....

Many of the challenges faced by both basic and clinical neuroscientists, such as ensuring the reproducibility of important findings and the representation of underserved populations, can be tackled with Open Science approaches Project Overview Many of the challenges faced by both basic and...

Optogenetics, defined as a technique where light-sensitive genes are introduced into brain cells to control their activity with light, allows researchers to precisely control nerve cell communication thereby, transforming brain research. Project Overview Optogenetics, defined as a technique where...