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The prevalence of autism spectrum disorders (ASDs) is rising dramatically on a yearly basis and new interventional strategies are required to treat ASDs and related disorders like Fragile X syndrome. Project Overview The prevalence of autism spectrum disorders (ASDs) is rising dramatically on a...

Amyotrophic lateral sclerosis (ALS) is a disease of progressive weakness that leads to death within a few years of onset. Project Overview Amyotrophic lateral sclerosis (ALS) is a disease of progressive weakness that leads to death within a few years of onset. The disease can start in one arm, leg,...

Dr. Eid will test the hypothesis that the Trio gene is a central regulator of the development and maturation of cortical interneurons (INs) and that its loss underlies some genetic forms of epileptic encephalopathies (EE) by disrupting cortical network development and function. Project Overview Dr....

“Increase your caloric intake.” This is the number one recommendation that a clinician will make to a person recently diagnosed with Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease affecting nerve cells in the brain and spinal cord, causing loss of muscle control. A high calorie...

The proposed research in this application will significantly broaden our understanding of the molecular basis for how stress leads to anxiety and depression. Project Overview The proposed research in this application will significantly broaden our understanding of the molecular basis for how stress...

Ms. Zeinab Mohanna’s research will test the hypothesis that CRISPR/Cas9-mediated genome editing can increase the expression of PAX6 protein, improve the function of the neural and other tissues of the eye, and ultimately rescue the mutant phenotype in the mouse model of aniridia. Project...

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS. Project Overview Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS. Recently, after...

Most nerves in the brain are surrounded by myelin, an insulating cover that allows them communicate efficiently. Project Overview Most nerves in the brain are surrounded by myelin, an insulating cover that allows them communicate efficiently. Brain damage in multiple sclerosis (MS) results from...

Most nerves in the brain are surrounded by myelin, an insulating cover that allows them communicate efficiently. Project Overview Most nerves in the brain are surrounded by myelin, an insulating cover that allows them communicate efficiently. Brain damage in multiple sclerosis (MS) results from...

Il se passe quelque chose de remarquable lorsqu'un jeune de 22 ans et une personne de 75 ans se trouvent côte à côte pour rouler de la pâte ou mélanger une salade d'inspiration thaïlandaise. Les conversations vont bon train. Les souvenirs remontent à la surface. Des compétences sont échangées. Telle...