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Development of a high throughput 3D microphysiologicalplatform for rapid automated assessment of human brain organoids response to drugs targeting neurological disorders
https://braincanada.ca/fr/subventions-financées/development-of-a-high-throughput-3d-microphysiologicalplatform-for-rapid-automated-assessment-of-human-brain-organoids-response-to-drugs-targeting-neurological-disordersAlzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common and devastating neurological diseases, with over 750,000 AD patients and over 100,000 PD patients in Canada. Project Overview Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common and devastating...
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Development of a shared decision-making aid for bulbar symptom management in ALS
https://braincanada.ca/fr/subventions-financées/development-of-a-shared-decision-making-aid-for-bulbar-symptom-management-in-alsBulbar disease, which affects speech and swallowing functions, is considered to be one of the most debilitating aspects of ALS by patients. Project Overview Bulbar disease, which affects speech and swallowing functions, is considered to be one of the most debilitating aspects of ALS by patients. It...
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Development of Genetic Screening Platforms for Immune Evasion in Glioblastoma
https://braincanada.ca/fr/subventions-financées/development-of-genetic-screening-platforms-for-immune-evasion-in-glioblastomaIn 2023, over 3,000 Canadians were newly diagnosed as brain tumor, and around 2,500 succumbed to this disease. Project Overview In 2023, over 3,000 Canadians were newly diagnosed as brain tumor, and around 2,500 succumbed to this disease. Despite strenuous efforts to fight against this serious...
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Development of novel oligonucleotide delivery modalities for Huntington disease
https://braincanada.ca/fr/subventions-financées/development-of-novel-oligonucleotide-delivery-modalities-for-huntington-diseaseHuntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world. Project Overview Huntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world. The...
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Developmental origins of stress and self-regulation and implications for interventions to improve childhood behavior
https://braincanada.ca/fr/subventions-financées/developmental-origins-of-stress-and-self-regulation-and-implications-for-interventions-to-improve-childhood-behaviorDr. Neuenschwander’s research aims to explore how exposure to stress during pregnancy affects children’s development, specifically in relation to children whose mothers were depressed and/or on antidepressants during pregnancy Project Overview Dr. Neuenschwander’s research aims to explore how...
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DIgital markers of Social Cognition for diagnosis & pRognosis in Neurodegeneration (DISCeRN)
https://braincanada.ca/fr/subventions-financées/digital-markers-of-social-cognition-for-diagnosis-prognosis-in-neurodegeneration-discernImpairments in social cognition (SC), such as difficulties in understanding emotions, social cues, and maintaining meaningful interactions, are key contributors to the loss of social inclusion and quality of life in individuals with neurodegenerative diseases (ND). Project Overview Impairments in...
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DIgital markers of Social Cognition for diagnosis & pRognosis in Neurodegeneration (DISCeRN)
https://braincanada.ca/fr/subventions-financées/digital-markers-of-social-cognition-for-diagnosis-prognosis-in-neurodegeneration-discern-2Impairments in social cognition (SC), such as difficulties in understanding emotions, social cues, and maintaining meaningful interactions, are key contributors to the loss of social inclusion and quality of life in individuals with neurodegenerative diseases (ND). Project Overview Impairments in...
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Direct microglial reprogramming to study Parkinson’s Disease
https://braincanada.ca/fr/subventions-financées/direct-microglial-reprogramming-to-study-parkinson-s-diseaseThe human brain is a complex organ that presents many challenges for neuroscientists. Project Overview The human brain is a complex organ that presents many challenges for neuroscientists. For instance, tissue availability represents a major problem given that this organ does not regenerates,...
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Discovering “hidden” causal mutations in autism using long-read RNAseq and proteomics in neuron development
https://braincanada.ca/fr/subventions-financées/discovering-hidden-causal-mutations-in-autism-using-long-read-rnaseq-and-proteomics-in-neuron-developmentAutism spectrum disorder (ASD) is a complex condition affecting communication, social interactions, and behavior in approximately 1–2% of people worldwide. Project Overview Autism spectrum disorder (ASD) is a complex condition affecting communication, social interactions, and behavior in...
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Discovering how brain cancer evolution affects responses to treatment
https://braincanada.ca/fr/subventions-financées/discovering-how-brain-cancer-evolution-affects-responses-to-treatmentA type of brain cancers called “diffuse gliomas” currently lacks effective treatments. Project Overview A type of brain cancers called “diffuse gliomas” currently lacks effective treatments. One obstacle to developing new therapies is the disease variability between patients. Several categories of...
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