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We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Project Overview We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Human induced...

Many people with dementia (PwD) live in nursing homes, which often suffer from a lack of skilled staff to support and monitor the safety of residents. Project Overview Many people with dementia (PwD) live in nursing homes, which often suffer from a lack of skilled staff to support and monitor the...

Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of developing cancer, particularly early in life. Project Overview Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of...

A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms. Project Overview A more streamlined way to diagnose ALS earlier is desperately needed as current methods can...

In the past decade, rapid development of software has allowed detection of a wide variety of genetic risk factors in brain disorders. Project Overview In the past decade, rapid development of software has allowed detection of a wide variety of genetic risk factors in brain disorders. It has...

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease leading to paralysis and death within 2-5 years from disease onset. Project Overview Amyotrophic lateral sclerosis (ALS) is a motor neuron disease leading to paralysis and death within 2-5 years from disease onset. Other hallmark...

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). Project Overview Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43...

We propose to develop a digital signature that identifies the level of care partner burden associated with person living with dementia (PLWD)/care partner dyads living in the community. Project Overview We propose to develop a digital signature that identifies the level of care partner burden...

Acute ischemic stroke represents the vast majority of strokes. Project Overview Acute ischemic stroke represents the vast majority of strokes. The priority in mitigating the impact is getting to hospital quickly. Once at the hospital we use medical imaging to determine the type of stroke and type...

Multiple sclerosis (MS) is a neurodegenerative disease in the brain and spinal cord of the central nervous system (CNS). Project Overview Multiple sclerosis (MS) is a neurodegenerative disease in the brain and spinal cord of the central nervous system (CNS). Canada has amongst the highest rate of...