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The four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72 Project Overview The four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72. Of these, TDP-43 and FUS have the most in common. Not only do they share similar functions inside cells, but in motor neurons...

Dr. Belzil began her research career as a PhD student at the Université de Montréal under the guidance of world renowned geneticist and Director of the Montreal Neurological Institute and Hospital, Dr. Guy Rouleau. Project Overview Dr. Belzil began her research career as a PhD student at the...

Proteins are large molecules that play many essential roles in the body. Project Overview Proteins are large molecules that play many essential roles in the body. They do most of the work inside cells and are necessary for the structure, function and regulation of all tissues and organs. TDP-43 is...

Many proteins in our brain are responsible for memory and learning. Project Overview Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas...

Parkinson’s disease and addiction have tremendous human and economical costs for our society. Project Overview Parkinson’s disease and addiction have tremendous human and economical costs for our society. The secret to understand these pathologies lies in unravelling the functioning of a specific...

Understanding how the brain works when we make decisions during social interactions has been difficult for neuroscientists. Project Overview Understanding how the brain works when we make decisions during social interactions has been difficult for neuroscientists. This is because our brains process...

Regular cannabis use is indisputably linked to schizophrenia. Project Overview Regular cannabis use is indisputably linked to schizophrenia. However, the causal nature and direction of this link is contentious and the biological mechanisms underpinning their relationship are poorly understood....

One of the most important advances in our understanding of chronic pain over the last decade or so is the realization that neurons are not the only cells in the central nervous system participating in the processing of pain signals. Project Overview One of the most important advances in our...

Rodent models offer an opportunity to understand the computations performed in neural circuits at a much precise scale than using human neuroimaging. Project Overview Rodent models offer an opportunity to understand the computations performed in neural circuits at a much precise scale than using...

Endogenous retrovirus-K (ERVK) is a genomic viral symbiont that contributes towards ALS neuropathology. Project Overview Endogenous retrovirus-K (ERVK) is a genomic viral symbiont that contributes towards ALS neuropathology. Our collaboration proposes to examine how ERVK integrase (IN) enzyme...