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Dynamic palmitoylation regulates TDP-43 nucleocytoplasmic transport in ALS
https://braincanada.ca/fr/subventions-financées/dynamic-palmitoylation-regulates-tdp-43-nucleocytoplasmic-transport-in-alsCommon features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death. Project Overview Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that...
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Dysregulation of integrated stress response (ISR) pathway in Fragile X syndrome and autism
https://braincanada.ca/fr/subventions-financées/dysregulation-of-integrated-stress-response-isr-pathway-in-fragile-x-syndrome-and-autismMr. Hooshmandi’s research will examine the hypothesis that reduced phosphorylation of eIF2α excessively stimulates general translation in Fmr1 KO mice during brain development, contributing to the pathophysiology of Fragile X syndrome (FXS) and potentially of other forms of autism. Project...
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Débloquer le cerveau pour débloquer l'avenir
https://braincanada.ca/fr/à-propos-de/nouvelles-mises-à-jour/déverrouiller-le-cerveau-pour-déverrouiller-l-avenirPHOTO : Le Dr Mark Cembrowski (à gauche) et le Dr Brian Kwon (à droite) ont reçu aujourd'hui à Vancouver des subventions de soutien aux plateformes de Brain Canada pour leurs recherches révolutionnaires en neurosciences au Djavad Mowafaghian Centre for Brain Health. Les chercheurs de la Faculté de...
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Démêler l’altération du système endocannabinoïde dans la SLA : une nouvelle méthode thérapeutique axée sur la jonction neuromusculaire
https://braincanada.ca/fr/subventions-financées/démêler-l-altération-du-système-endocannabinoïde-dans-la-sla-une-nouvelle-méthode-thérapeutique-axée-sur-la-jonction-neuromusculaireA hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in muscle weakness and paralysis. Project Overview A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in...
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Early Brain Development Following Prenatal Exposure to SSRI Antidepressants and Maternal Depression
https://braincanada.ca/fr/subventions-financées/early-brain-development-following-prenatal-exposure-to-ssri-antidepressants-and-maternal-depressionza Many women experience depression during pregnancy, and are often faced with challenging decisions surrounding antidepressant use during this critical time for their developing child. Project Overview Many women experience depression during pregnancy, and are often faced with challenging...
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Early diagnosis of gliomas by using a novel multiplexed serum proteomic technology
https://braincanada.ca/fr/subventions-financées/early-diagnosis-of-gliomas-by-using-a-novel-multiplexed-serum-proteomic-technologyNeed for project: Gliomas are among the most malignant tumors, with very poor survival rates. Project Overview Need for project: Gliomas are among the most malignant tumors, with very poor survival rates. Early diagnosis is highly desirable since it can facilitate more effective treatments of small...
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Early Intervention for Youth Suicide: Leveraging EEG to Predict Treatment Response and Suicidality in the TIDE Trial
https://braincanada.ca/fr/subventions-financées/early-intervention-for-youth-suicide-leveraging-eeg-to-predict-treatment-response-and-suicidality-in-the-tide-trialDepression is one of the most common mental health challenges faced by young people, yet choosing the right treatment remains a process of trial and error. Project Overview Depression is one of the most common mental health challenges faced by young people, yet choosing the right treatment remains...
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Early Postnatal Metabolic Treatment for the Fetal Alcohol Syndrome
https://braincanada.ca/fr/subventions-financées/early-postnatal-metabolic-treatment-for-the-fetal-alcohol-syndromeFetal Alcohol Syndrome (FAS) is the result of in utero alcohol exposure and is characterized by central nervous system developmental impairments which causes lifelong physical and cognitive disabilities. Project Overview Fetal Alcohol Syndrome (FAS) is the result of in utero alcohol exposure and is...
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Early Years Intervention on a First Nations Reserve
https://braincanada.ca/fr/subventions-financées/early-years-intervention-on-a-first-nations-reserveRecognizing that the 9 months before birth and the early years of a child’s life are the most critical period in the shaping of the structures and functions of the brain, and the importance of high quality, culturally appropriate early childhood programming for Indigenous children and families prior...
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Effects of C9orf72 Deficiency on Inducing Neuronal Hyperexcitability In Vivo
https://braincanada.ca/fr/subventions-financées/effects-of-c9orf72-deficiency-on-inducing-neuronal-hyperexcitability-in-vivoA G4C2 repeat expansion in C9orf72 (chromosome 9 open reading frame 72), a gene of unclear function, is the most frequent genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (C9-ALS/FTD). Project Overview A G4C2 repeat expansion in C9orf72 (chromosome 9 open reading...