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Le projet Alex Parker et son équipe se concentrent sur le développement et l'utilisation de modèles simples pour étudier les maladies du cerveau, en particulier la SLA. Le système modèle qu'ils utilisent est le ver Caenorhabditis elegans (C. elegans). Ce petit ver transparent ne possède que 300...

When brain cells are injured during Alzheimer’s disease, those cells may either die or become too electrically excitable. Project Overview When brain cells are injured during Alzheimer’s disease, those cells may either die or become too electrically excitable. This study’s objective is to design...

We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Project Overview We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Human induced...

Many people with dementia (PwD) live in nursing homes, which often suffer from a lack of skilled staff to support and monitor the safety of residents. Project Overview Many people with dementia (PwD) live in nursing homes, which often suffer from a lack of skilled staff to support and monitor the...

Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of developing cancer, particularly early in life. Project Overview Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of...

A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms. Project Overview A more streamlined way to diagnose ALS earlier is desperately needed as current methods can...

In the past decade, rapid development of software has allowed detection of a wide variety of genetic risk factors in brain disorders. Project Overview In the past decade, rapid development of software has allowed detection of a wide variety of genetic risk factors in brain disorders. It has...

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease leading to paralysis and death within 2-5 years from disease onset. Project Overview Amyotrophic lateral sclerosis (ALS) is a motor neuron disease leading to paralysis and death within 2-5 years from disease onset. Other hallmark...

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). Project Overview Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43...

Maria Stepanova, physicienne à l'Université de l'Alberta, est l'une des neuf récipiendaires de la subvention à la découverte de 2022 de SLA Canada-Cerveau Canada. Elle travaille en étroite collaboration avec le Dr Holger Wille, biologiste structurel également à l'Université de l'Alberta. Bien que...