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This research proposal investigates how a chemical modification called N6-methyladenosine (m6A) on messenger RNA influences brain health, specifically focusing on its role in sleep regulation, learning and memory, and neurodegenerative diseases such as Alzheimer’s. This research proposal...

Dr Christopher E. Pearson (à gauche) et Dr Ekaterina Rogaeva Le contrôle de l'expansion d'une répétition d'ADN peut indiquer la voie à suivre pour un traitement futur "La meilleure chose à faire en tant que scientifique dans ce domaine, ce sont les personnes avec lesquelles nous travaillons et les...

Age-related dementias are reaching epidemic levels, affecting over 600,000 Canadians. Project Overview Age-related dementias are reaching epidemic levels, affecting over 600,000 Canadians. The most common cause of age-related dementia is Alzheimer’s disease (AD). The defining pathology of AD is the...

Systems neuroscience owes much of its success to an empirical tradition of using simplified laboratory settings that carefully control sensory stimuli, motor responses, or other task-relevant variables in order to identify the neural mechanisms underlying different behavioral functions. Project...

Many youth suffer from mental health-related brain disorders which can have devastating consequences Effective treatment is desperately needed. Project Overview Many youth suffer from mental health-related brain disorders which can have devastating consequences Effective treatment is desperately...

"Background:Within the realm of neurodegenerative diseases, there is still a lack of effective disease-modifying treatments. Huntington’s Disease (HD) is no less immune to this issue, with only symptomatic treatment options being available for patients." Project Overview “Background:Within the...

Alzheimer’s Disease (AD) is characterized by memory decline and neuronal pathology, including amyloid β (Aβ)plaques and oxidative stress. Project Overview Alzheimer’s Disease (AD) is characterized by memory decline and neuronal pathology, including amyloid β (Aβ)plaques and oxidative stress. These...

Recent findings suggest that the gut and brain are closely connected, and this link may be important in Alzheimer’s disease (AD). Project Overview Recent findings suggest that the gut and brain are closely connected, and this link may be important in Alzheimer’s disease (AD). Helpful products made...

Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP). Project Overview Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP). The ischemic event leaves most...

Dr. Garzia works on a type of pediatric brain cancer called medulloblastoma. Project Overview Dr. Garzia works on a type of pediatric brain cancer called medulloblastoma. Kids affected by this tumor are either not cured or experience severe side effects due to the aggressive therapy. This proposal...