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A pathologic feature in both sporadic and familial ALS patients is the presence of large neuronal inclusions enriched with misfolded proteins, including SOD1, TDP43 and FUS that are frequently modified with the small protein ubiquitin (Ub) Project Overview A pathologic feature in both sporadic and...

The emerging consensus that the brain functions as a single, complex system has led to the popularity of a network approach to studying brain function. Functional connectivity, a measure of the coordinated activity between brain regions, has been observed in neuroimaging studies to change during...

Substance use during pregnancy can have negative effects on infants, including congenital disabilities, delayed neurodevelopment, and long-term learning difficulties. Project Overview Substance use during pregnancy can have negative effects on infants, including congenital disabilities, delayed...

This research aims to unravel the mysteries of Rett syndrome (RTT), a severe neurodevelopmental condition primarily affecting girls, characterized by mental and physical impairments. Project Overview This research aims to unravel the mysteries of Rett syndrome (RTT), a severe neurodevelopmental...

The lifetime risk of developing amyotrophic lateral sclerosis (ALS) is approximately 1 in 350 for men and 1 in 440 for women, making it the most common adult-onset motor neuron disease. Project Overview The lifetime risk of developing amyotrophic lateral sclerosis (ALS) is approximately 1 in 350...

In general, women take part in research less than men. Project Overview In general, women take part in research less than men. We found women take part in our research less than men too. We are a team of rehabilitation researchers located across Canada that test new treatments like drugs,...

Membre estimé de notre conseil d’administration, Eddie a apporté à notre organisation une sagesse et un leadership exceptionnels. Tout au long d’une remarquable carrière dans la fonction publique, le droit, les politiques publiques et la gouvernance, il s’est distingué par son intelligence, la...

Depression and bipolar disorder, known as mood disorders, significantly impact the lives of many Canadians, especially women and the LGBTQ+ community. Although many treatments are available, it is often challenging for clinicians to determine which treatment is the right one for a particular...

Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. Project Overview Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match...

Neurological disorders affect more than 1 in 3 people, making them a leading cause of illness and disability worldwide. Project Overview Neurological disorders affect more than 1 in 3 people, making them a leading cause of illness and disability worldwide. Currently, there are no effective...