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Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ. Project Overview Autism spectrum disorders (ASD) and schizophrenia...

The project provides state of the art mouse brain imaging to researchers in Canada working on models of neurodevelopmental disorders. Project Overview The project provides state of the art mouse brain imaging to researchers in Canada working on models of neurodevelopmental disorders. The use of...

Neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease profoundly affect aspects of cognition including memory Project Overview Neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease profoundly affect aspects of cognition including memory, attention, decision...

A biological marker, or “biomarker” for short, is a measurable indicator associated with a disease state that helps determine risk, severity and response to therapy. Project Overview A biological marker, or “biomarker” for short, is a measurable indicator associated with a disease state that helps...

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the world. Project Overview Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the world. PD can manifest and develop in a variety of ways for different patients, and it is currently not...

Autism spectrum disorder (ASD) affects approximately 1 in 70 children and is associated to a considerable burden for affected individuals, their families, and health care at large. Project Overview Autism spectrum disorder (ASD) affects approximately 1 in 70 children and is associated to a...

In ALS, the disease is characterized by degeneration of motor neurons and an inability of the brain to signal the muscles to move, resulting in paralysis. Project Overview In ALS, the disease is characterized by degeneration of motor neurons and an inability of the brain to signal the muscles to...

Even though memory loss is one of the most debilitating features of dementia, several studies has revealed the ability of music to trigger the recall of old memories is relatively preserved in people living with dementia. Yet, we don’t exactly what feature of music activates memories. This goal of...

In 2019, a team of scientists led by co-recipient Dr. Sali Farhan discovered a new genetic cause of ALS called DNAJC7. Project Overview In 2019, a team of scientists led by co-recipient Dr. Sali Farhan discovered a new genetic cause of ALS called DNAJC7. Subsequent work revealed that mutations in...

Does SARS-CoV-2 infection increase cognitive decline via myelin loss in older individuals? Project Overview Does SARS-CoV-2 infection increase cognitive decline via myelin loss in older individuals? Background: One in 4 persons infected with SARS-CoV-2 (the COVID-19 virus) shows cognitive decline....