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Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma
https://braincanada.ca/fr/subventions-financées/using-synthetic-antibody-parts-to-construct-antibody-based-imaging-devices-anti-egfr-molecular-targeted-imaging-probes-for-diagnosing-and-monitoring-glioblastomaTo improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy. Project Overview To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and...
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Using targeted ultrasound to get immunotherapy drugs past the blood-brain barrier
https://braincanada.ca/fr/subventions-financées/using-targeted-ultrasound-to-get-immunotherapy-drugs-past-the-blood-brain-barrierStephanie Borlase is investigating ways to improve immunotherapies to treat people whose lung cancer has spread to the brain, improving outcomes. Project Overview Stephanie Borlase is investigating ways to improve immunotherapies to treat people whose lung cancer has spread to the brain, improving...
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Utilizing next generation intersectional approaches to define the roles of POMC neuron subpopulations
https://braincanada.ca/fr/subventions-financées/utilizing-next-generation-intersectional-approaches-to-define-the-roles-of-pomc-neuron-subpopulationsThe central nervous system controls numerous processes, including appetite and body weight regulation. Project Overview The central nervous system controls numerous processes, including appetite and body weight regulation. Given the alarming rise in global obesity, understanding how the CNS...
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Validation of cognitive rehabilitation program adapted to the needs of adults with brain cancer and adult survivors of childhood brain cancer.
https://braincanada.ca/fr/subventions-financées/validation-of-cognitive-rehabilitation-program-adapted-to-the-needs-of-adults-with-brain-cancer-and-adult-survivors-of-childhood-brain-cancerWe propose a randomized controlled trial to evaluate the efficacy of Goal Management Training (GMT) for improving these patients’ cognitive functioning as well as patient and caregiver QoL. Project Overview We propose a randomized controlled trial to evaluate the efficacy of Goal Management...
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Validation of Connexins and Pannexins as a target for Alzheimer’s Disease
https://braincanada.ca/fr/subventions-financées/validation-of-connexins-and-pannexins-as-a-target-for-alzheimer-s-diseaseAlzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. Project Overview Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As...
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Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration
https://braincanada.ca/fr/subventions-financées/validation-of-ocular-measures-as-potential-biomarkers-for-early-detection-of-brain-amyloid-and-neurodegeneration500,000 Canadians have dementia, a number that will double within a generation due to the ongoing aging demographics of the population, with annual costs estimated to increase from $15B currently to over $150B by the year 2050. Project Overview 500,000 Canadians have dementia, a number that will...
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Validation of small molecules preventing TDP-43 aggregation as a therapeutic for Amyotrophic Lateral Sclerosis
https://braincanada.ca/fr/subventions-financées/validation-of-small-molecules-preventing-tdp-43-aggregation-as-a-therapeutic-for-amyotrophic-lateral-sclerosisTDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. Project Overview TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. It is usually found in the nucleus, but in people with ALS, it becomes trapped...
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Vascular innervation and blood-brain barrier dysfunction in Huntington’s disease using human iPSC-derived vascularized brain organoids.
https://braincanada.ca/fr/subventions-financées/vascular-innervation-and-blood-brain-barrier-dysfunction-in-huntington-s-disease-using-human-ipsc-derived-vascularized-brain-organoids“Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been documented in Huntington’s disease (HD). Project Overview “Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been...
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Vascular Interface with the Brain and Neurocognition via the Eyes (VIBE): Retinal Photography in Youth with Psychiatric Disorders
https://braincanada.ca/fr/subventions-financées/vascular-interface-with-the-brain-and-neurocognition-via-the-eyes-vibe-retinal-photography-in-youth-with-psychiatric-disordersThe goal of this study is to advance knowledge regarding the association of vascular risk factors and blood vessels with brain structure and function in youth with severe mental illness. Project Overview The goal of this study is to advance knowledge regarding the association of vascular risk...
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Verifying aerobic training protocols to benefit both heart and brain in subacute stroke
https://braincanada.ca/fr/subventions-financées/verifying-aerobic-training-protocols-to-benefit-both-heart-and-brain-in-subacute-strokeBecause of low fitness and heart problems, people with stroke are at very high risk of a second stroke or heart attack within 10 years. Project Overview Because of low fitness and heart problems, people with stroke are at very high risk of a second stroke or heart attack within 10 years. Exercise...
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