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Mutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or even...

Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. Project Overview Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. There is a recent and growing false belief that Cannabis can reduce nausea during...

Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few effective treatment options. Project Overview Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few...

Brain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain cancer of childhood. Project Overview Brain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain...

Pediatric high-grade gliomas are incurable brain cancers. Project Overview Pediatric high-grade gliomas are incurable brain cancers. Sequencing the tumor specimens has shown that most cases do not have obvious mutations that are known to cause cancer. It is therefore not known what causes, or...

Amyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ). Project Overview Amyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ). This can be one of the earliest pathological processes...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of motor neurons and the atrophy of muscles. Project Overview Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of motor neurons and the atrophy of...

In this study, we. aim to do two things: 1) monitor the distribution of a-Syn in Parkinson’s disease (PD) context to understand the factors that can cause a-Syn to build-up in certain cells of the brain, called microglia. Project Overview In this study, we. aim to do two things: 1) monitor the...

Dr. Shmuel and his team are establishing a local platform which will support functional MRI (fMRI) in the alert non-human primate brain. Project Overview Dr. Shmuel and his team are establishing a local platform which will support functional MRI (fMRI) in the alert non-human primate brain. The...