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One of the hallmarks of ALS is the presence of abnormal clumps inside motor neurons that contain various substances which include, in the majority of cases, something called TAR DNA–binding protein 43 (TDP-43). Project Overview One of the hallmarks of ALS is the presence of abnormal clumps inside...

No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Project Overview No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Several dramatic late stage clinical failures have heightened recognition that novel approaches...

Concussions frequently occur worldwide, with a subset of patients experiencing lasting symptoms impacting their quality of life. Project Overview Concussions frequently occur worldwide, with a subset of patients experiencing lasting symptoms impacting their quality of life. Sub-concussive injuries,...

Une équipe de recherche internationale dirigée par la Dre Fang Liu, du Centre de toxicomanie et de santé mentale (CAMH), a reçu près de 800 000 $ US (1 137 868 $ CA) de nouveaux fonds pour faire progresser un traitement prometteur de la sclérose en plaques. Dre Fang Liu, Scientifique principale,...

Dr.  Hutchison‘s training is in lifespan psychology and her research broadly focuses on children’s cognitive and social development. Project Overview Dr.  Hutchison‘s training is in lifespan psychology and her research broadly focuses on children’s cognitive and social development. her current...

Primary progressive aphasia (PPA) is a form of dementia which impairs the ability to understand spoken and written language but other cognitive skills (including memory) remain intact for several years after its onset. Project Overview Primary progressive aphasia (PPA) is a form of dementia which...

This project is studying a novel intervention in 250 older persons whose major depression has been successfully treated with an antidepressant medication: a combination of cognitive remediation (CR, consisting of memory and problem solving exercises) plus transcranial Direct Current Stimulation...

RNA medicines—short strands of nucleic acids that can turn genes “up” or “down”—have changed how we treat brain diseases. For example, nusinersen for spinal muscular atrophy and tofersen for ALS are given by spinal injection to reach the brain and spinal cord. These breakthroughs show that RNA drugs...

Progressive Supranuclear Palsy (PSP) is a deadly disease of the brain with no cure. Project Overview Progressive Supranuclear Palsy (PSP) is a deadly disease of the brain with no cure. By studying the brains of patients who have died scientists have discovered that PSP brains contain toxic deposits...