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815 résultats trouvés

Relating hippocampal pathways to human learning

The human experience is marked by constant learning.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Système nerveux central
Concours
Les futurs leaders de la recherche sur le cerveau au Canada
Province
Ontario
DATE DE DÉBUT
2020

Disrupted SUMOylation facilitates rogue TDP-43 in ALS

Proteins are large molecules that play many essential roles in the body.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2019

Biological and Pathological relevance of hnRNP A1B; An alternative splice variant of TDP-43

In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43 protein is misplaced to an area outside the cell nucleus of the motor neuron called the cytoplasm.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2019

Validation of small molecules preventing TDP-43 aggregation as a therapeutic for Amyotrophic Lateral Sclerosis

TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2019

2019 Turnbull-Tator Award in Spinal Cord Injury and Concussion Research


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Blessures
Concours
Bourse Turnbull-Tator pour la recherche sur les lésions de la moelle épinière et les commotions cérébrales
Province
Colombie-Britannique
DATE DE DÉBUT
2019

Exploitation of a new pharmacological target for the development and validation of new anti-inflammatory drugs

Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis  to  Alzheimer’s  disease.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Concours
CQDM - Brain Canada - SynergiQc
Province
Québec
DATE DE DÉBUT
2019

Systematic assessment of retinal output following optogenetic vision therapy

Optogenetic strategies – the ability to activate normally light-insensitive neurons with light – are being used in clinical trials to restore light sensitivity to the retina of vision impaired patients.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Système nerveux central
Province
Québec
DATE DE DÉBUT
2019

Neurodegenerative potential for microglia in a progressive MS model

Multiple Sclerosis (MS) is a disease where the immune system attacks the brain and spinal cord.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Alberta
DATE DE DÉBUT
2019

Electrically guided transcranial stimulation of cells chemogenically primed for excitability a novel, non-invasive and cell type-specific approach

Dr Bambico proposes to test a new and potentially groundbreaking experimental technique called EC stimulation, which will enable researchers to influence the activity of different kinds of neurons in any part of the brain without the need of major brain invasive surgery or complex genetic techniques.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Système nerveux central
Province
Terre-Neuve et Labrador
DATE DE DÉBUT
2019

Decoding the RNA stability programs that determine cell identity and function in human brain and neurodegenerative disorders

The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2019