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815 résultats trouvés

Mapping the cellular origins of circuit vulnerability in neurodevelopmental disorders

The brain is an incredibly complex organ. Much of the brain’s complexity may be attributed to the circuitry that resides within.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Système nerveux central
Province
Ontario
DATE DE DÉBUT
2018

Detection of misfolded TDP-43 in CSF of ALS cases: Diagnostic potential of confirmation-specific antibodies

A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2018

Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons

A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2018

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2018

Characterizing Enterovirus Disruption of Autophagy as a Disease Mechanism for ALS

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2018

Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2018

MRI Biomarkers of Cerebral Degeneration in ALS and their Pathological Validation

A biological marker, or “biomarker” for short, is a measurable indicator associated with a disease state that helps determine risk, severity and response to therapy.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Alberta
DATE DE DÉBUT
2018

The Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis (CanProCo)

Progression – or the steady worsening of disease and increase in disability – is a challenging reality faced by people affected by MS, and despite major advances in MS research, the mechanism of progression and the ways in which researchers and clinicians can track progression are still not fully understood.


TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurodégénérescence
Concours
Cohorte de progression de la SEP
Province
Ontario
DATE DE DÉBUT
2018

Canadian Open Parkinson Network (C-OPN)

The Canadian Open Parkinson Network, or C-OPN, is a national network that unites researchers, physicians and patients across Canada to study Parkinson’s disease (PD).


TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurodégénérescence
Concours
Autres
Province
Alberta
DATE DE DÉBUT
2018

A Drug Screening Platform to Increase Protein Expression Levels for Treatment of Neurological Disorders

Neurological and psychiatric diseases and disorders affect more than half the population.


TYPE DE SUBVENTION
Subventions de la plate-forme
Domaine de recherche
Neurotechnologie
Concours
CQDM - Brain Canada - Quantum Leap
Province
Québec
DATE DE DÉBUT
2018