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815 résultats trouvés

Combining neurostimulation technique with tailored interventions for the affected upper extremity: can it promote better recovery in stroke survivors?

A substantial proportion of individuals are left with poor residual functioning of the affected arm after a stroke.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Blessures
Province
Québec
DATE DE DÉBUT
2017

Sleep, cognition, and inflammation following natural or surgical menopause

Alzheimer’s disease disproportionately affects women and emerging evidence suggests there may be unique biological and lifestyle factors that underlie these differences.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2017

Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells

Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2017

Generating expanded repeats in the C9ORF72 ortholog in zebrafish

Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2017

Development of novel oligonucleotide delivery modalities for Huntington disease

Huntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Colombie-Britannique
DATE DE DÉBUT
2017

Northern Lights collaboration for better 2-photon probes

The Northern Lights collaboration for better 2-photon probes will combine the expertise of four very different investigators and laboratories from Montana and Canada with complementary interests and skills to tackle a fundamental problem in imaging of the activity of the living brain.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurotechnologie
Province
Alberta
DATE DE DÉBUT
2017

Neuroinflammatory susceptibility to vascular disease as a dementia driver

Recent studies have shown that damage to the small blood vessels in the brain (cerebrovascular disease) may increase the risk for Alzheimer’s.


TYPE DE SUBVENTION
Subventions pour le renforcement des capacités
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2017

Pathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery

In this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS.


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Ontario
DATE DE DÉBUT
2017

A patient-derived iPSC platform of disease relevant cell models for biological studies

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs).


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2017

Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly


TYPE DE SUBVENTION
Subventions d'équipe
Domaine de recherche
Neurodégénérescence
Province
Québec
DATE DE DÉBUT
2017