Subventions financées

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape.

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells.

Many scientists believe that one of the earliest abnormalities in ALS is dysfunction at the place where motor neurons connect to muscle, known as the neuromuscular junction (NMJ).

The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to another.

Dr. Patten started his research career as a PhD student at the University of Alberta under the supervision of Dr. Declan Ali in 2004.

This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction.

Membrane proteins are biological molecules of incredible importance, playing diverse roles in many processes critical to life.

One of the most important questions of biomedical research is “why do we ail as we age?”.

Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ.

To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy.