Subventions financées

Major depression is common, highly prevalent, potentially lethal, affecting 10% of individuals with significant increase between 2015-2020, and 2-3-fold higher incidence in women compared to men.

We identified changes in the gene called IRF2BPL (Interferon Regulatory Factor 2 Binding Protein Like) as the cause of a severe brain disorder in children called NEDAMSS (Neurodevelopmental disorder with abnormal movements, loss of speech and seizures).

The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral blood flow (CBF) regulation in different regions of their brain.

“La bonne intervention, au bon moment, pour le bon enfant”.

Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death.

Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons, neurons that control the muscles to generate fundamental movements in our daily life, are gradually destroyed during the disease leading to paralysis and eventually death.

Pregnancy and the postpartum period are high risk for depression onset and other psychiatric disorders in the birthing parent.

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy, recommended by Canadian guidelines as a first-line intervention for major depression that does not respond to an adequate course of pharmacological therapy, known as treatment-resistant depression (TRD).

In the era of climate change-related disasters and a globally disruptive pandemic, people worldwide are grappling with the question of how to foster resilience.

By profiling the protein expression signatures of multiple patient-derived glioblastoma cell lines, we recently identified a major signalling pathway involved in glioblastoma cell migration.