Project Overview
The brain is one of the most energy-demanding organs in the body, yet it has no energy reserves. To function properly, it relies on a finely tuned process that increases local blood flow whenever neurons become active: a process known as neurovascular coupling (NVC). This link between brain activity and blood flow is what allows brain imaging techniques like functional MRI (fMRI) to visualize “brain activity.” Despite its importance, we still don’t fully understand how different types of brain cells control this process.
Traditionally, scientists have thought that blood flow changes are mainly driven by excitatory neurons, the cells that send activating signals in the brain. However, recent evidence suggests that another group of neurons, called inhibitory interneurons, may also play a major role by directly releasing substances that can relax or constrict blood vessels. These interneurons could therefore fine-tune the brain’s blood supply and help explain why blood flow signals vary so much across different regions.
In this project, we will use advanced imaging methods to observe the activity of specific types of inhibitory neurons and the resulting changes in local blood flow in the brains of mice during a sensory touch stimulation. By silencing or activating these cells, we will determine how they influence the strength and timing of blood flow responses.
Understanding how inhibitory neurons shape blood flow will deepen our knowledge of brain function and improve how we interpret fMRI signals, with implications for studying brain disorders that affect circulation, such as stroke, dementia, and epilepsy.
Partners and Donors
Heart and Stroke Foundation
