Directory of funded grants

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774 results found

The application of 3D models to assess the role of microglia in neurodegenerative disorders

  • Grant Type

    Platform grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    CQDM - Brain Canada - Quantum Leap

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $2,683,914

  • Health Canada Contribution

    $500,000

Project Overview

Challenge: Alzheimer’s disease (AD) is characterized by a decline in cognitive function, yet it is now widely acknowledged that as the disease advances, dopaminergic neurons in the midbrain become particularly vulnerable, leading to non-cognitive symptoms such as motor dysfunction. While microglia, the immune cells resident in the central nervous system,…

Project Ongoing

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Precision Metabolism: Deciphering and Targeting Metabolic Adaptations in Therapy-Resistant Recurrent Glioblastoma

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Manitoba

  • Start Date

    2024

  • Total Grant Amount

    $130,000

  • Health Canada Contribution

    $65,000

Project Overview

Glioblastoma (GBM) is a common and deadly brain cancer in adults. Doctors use strong medicine (chemotherapy) and special rays (radiation therapy) to treat it. However, 80-90% of patients see the cancer come back, and the usual treatments don't work anymore. This project aims to find out why GBM comes back…

Project Ongoing

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Targeting the immune suppressive microenvironment in histone 3-mutant high-grade gliomas

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $130,000

  • Health Canada Contribution

    $65,000

Project Overview

The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells in cancer, we can understand how they promote tumor progression. In this project, our goal is to modify the activity of a…

Project Ongoing

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Impact of 2-hydroxyglutarate-induced astrocytes reactivity in low-grade glioma progression and recurrence

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $130,000

  • Health Canada Contribution

    $65,000

Project Overview

Mutations in the metabolic enzymes are commonly observed in brain cancers. Although the precise molecular underpinning for this remains elusive, it has been shown that brain cancer-associated mutations in metabolic pathways confer altered metabolic function by increasing production of the oncogenic metabolite R-2-Hydroxyglutarate (R-2HG). This metabolite was shown to promote…

Project Ongoing

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Specific translation of mRNAs encoding primary cilia components as a new resistance mechanism in glioblastoma

  • Grant Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    CRS Operating Grants

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $130,000

  • Health Canada Contribution

    $65,000

Project Overview

We are studying a type of brain tumour called glioblastoma (GBM), which is often fatal despite current treatments. Our team developed a new technique to analyze a specific part of the tumour's molecular makeup and found three subtypes with different survival rates. One subtype, called "Ciliary," stands out because of…

Project Ongoing

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