720 results found
Post-mortem human hippocampal neuroplasticity, cognition, and late-life physical activity: Importance of biological sex and cognitive health status
Project Overview
The world population is rapidly aging; there is a real need for effective, personalized lifestyle recommendations for promoting healthy cognitive aging. Physical activity is a promising strategy for healthy brain aging. However, we lack prerequisite knowledge that will improve its utility and effectiveness. Specifically, we do not now for whom…
Project Ongoing
See the project and researchersElucidating the Role of DNA Repair Mechanisms in Neurodevelopmental Disorders
Project Overview
This research aims to unravel the mysteries of Rett syndrome (RTT), a severe neurodevelopmental condition primarily affecting girls, characterized by mental and physical impairments. The focus is on the role of two proteins, Fanconi Anemia Group J protein (Fan1) and methyl CpG binding protein-2 (MECP2), which are essential for the…
Project Ongoing
See the project and researchersElucidating the neurobiological impact of neonatal polydrug exposure
Project Overview
Substance use during pregnancy can have negative effects on infants, including congenital disabilities, delayed neurodevelopment, and long-term learning difficulties. In Canada alone, it is estimated that up to 5% of all infants are exposed to multiple substances, which amounts to around 15,000 births annually. Unfortunately, there is no known cure…
Project Ongoing
See the project and researchersSensory development and integration in the common marmoset
Project Overview
In everyday life, we are solicited by numerous stimulations coming from different sensory modalities (e.g., visual, tactile, auditory…). These stimuli are integrated separately or combined by the brain to provide the right response. The integration of multisensory information plays a key role in the development of cognitive processes such as…
Project Ongoing
See the project and researchersDeveloping vascularized brain-on-chip technologies: the next frontier in neuroscientific research
Project Overview
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and the fastest growing neurodegenerative disorder worldwide. However, despite extensive investigation, most clinical trials failed to translate promising findings into drugs for people living with the disease. As of today, there is no therapy that can stop…